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Electrochemical Micro- and Nanobiosensors for in Vivo Reactive Oxygen/Nitrogen Species Measurement in the Brain Publisher



Beigloo F1 ; Khoshkarvandi SA2 ; Pourmand E3 ; Heydari M4 ; Molaabasi F5 ; Gharib N6 ; Zare Y5 ; Rhee KY7 ; Park SJ8
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Tehran Valiasr Technical University, Kianshahr, Tehran, Iran
  2. 2. Department of Chemistry, Nanotechnology Research Center, South Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Chemistry, Alzahra University, Tehran, Iran
  4. 4. Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran
  5. 5. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  6. 6. College of Engineering and Technology, American University of the Middle East, Egaila, 54200, Kuwait
  7. 7. Department of Mechanical Engineering (BK21 four), College of Engineering, Kyung Hee University, Yongin, South Korea
  8. 8. Department of Chemistry, Inha University, Incheon, 22212, South Korea

Source: Nanotechnology Reviews Published:2023


Abstract

In this focused review, we examine the influence of reactive oxygen and nitrogen species (ROS/RNS) on physiological processes and the induction of oxidative stress, with particular emphasis on the brain and neuronal systems. We discuss the formation mechanisms of ROS and RNS, their significance in the brain, and various detection methods. The review investigates the latest advancements in nano-engineered electrochemical biosensors designed for in vivo monitoring of ROS and RNS in the brain tissue. We explore the electrochemical measurement of specific species, such as H2O2, superoxide, NO, and peroxynitrite, while providing a comparative evaluation of sensor designs for ROS and RNS detection in the brain. Finally, we offer an outlook and conclusion on the future of this field. © 2023 the author(s), published by De Gruyter.