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Co3o4 Nanoparticles Embedded in Electrospun Carbon Nanofibers As Free-Standing Nanocomposite Electrodes As Highly Sensitive Enzyme-Free Glucose Biosensors Publisher



Mohammadpourharatbar A4 ; Mosallanejad B5 ; Zare Y1 ; Rhee KY2 ; Park SJ3
Authors
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Authors Affiliations
  1. 1. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  2. 2. Department of Mechanical Engineering (BK21 four), College of Engineering, Kyung Hee University, Yongin, South Korea
  3. 3. Department of Chemistry, Inha University, Incheon, 22212, South Korea
  4. 4. Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, Tehran, Iran
  5. 5. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran

Source: Reviews on Advanced Materials Science Published:2022


Abstract

Numerous researches have been directed toward enzyme-free biosensors to alleviate the shortcomings encountered with enzymatic biosensors, in particular the intricate enzyme immobilization procedure. Herein, Co3O4/electrospun carbon nanofiber (ECNF) nanocomposites are successfully prepared to be employed as enzyme-free biosensors for diagnosis of glucose. Two parameters including the carbonization time and the amount of Cobalt(II) acetate tetrahydrate precursor are optimized, which are 5 h and 0.5 g, respectively. The 0.5 Co3O4/ECNF-5 h nanocomposite delivers superior sensitivity (475.72 μA·mM−1·cm−2), broad linear range (2–10 mM), and detection limit (LOD) less than 1 mM (0.82 Mm). In addition, the electrode shows excellent selectivity. The chronoamperometric analysis of 0.5 Co3O4/ECNF-5 h nanocomposite is performed by adding successively glucose analyte and interfering agents to the 0.1 M sodium hydroxide solution. No significant amperometric signal to the interfering agents including uric acid, ascorbic acid, and dopamine is delivered by this electrode, testifying the great selectivity of the electrode toward the diagnosis of target analyte (glucose) in spite of the existence of interfering species. Taking the aforementioned explanations into account, it can be concluded that the Co3O4/ECNF nanocomposite can be an appropriate free-stand electrode for high-performance enzyme-free glucose biosensor. © 2022 Ali Mohammadpour-Haratbar et al.
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