Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies

Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies Publisher Pubmed

Akbari Javar H¹ ; Garkaninejad Z² ; Dehghannoudeh G³ ; Mahmoudimoghaddam H^{3, 4}

Show Affiliations

1. Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Chemistry Department, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
3. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Analytica Chimica Acta Published:2020

Abstract

The present research reported a new electrochemical biosensor based on ds-DNA/Eu3+ doped NiO/CPE to detect amsacrine. Therefore, UV–Vis spectrophotometry, docking, and differential pulse voltammetry (DPV) have been used to study the interactions between amsacrine and dsDNA. Then, experimental parameters affected DNA immobilization and interactions between amsacrine and ds-DNA have been optimized. Afterwards, guanine oxidation peak current of ds-DNA has been chosen as a signal to analyze amsacrine in a concentration ranging between 0.1 and 100.0 μM and finally, limit of detection (LOD) of 0.05 μM has been calculated at optimal condition. Ultimately, it was found that the suggested biosensor is able to determine amsacrine in human serum and urine samples successfully. © 2020 Elsevier B.V.

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Experts (# of related papers)

Hamid Akbari Javar (3)

Style	Citing Format
MLA	Akbari Javar H, et al.. "Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies." Analytica Chimica Acta, vol. 1133, no. , 2020, pp. 48-57.
APA	Akbari Javar H, Garkaninejad Z, Dehghannoudeh G, Mahmoudimoghaddam H (2020). Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies. Analytica Chimica Acta, 1133(), 48-57.
Chicago	Akbari Javar H, Garkaninejad Z, Dehghannoudeh G, Mahmoudimoghaddam H. "Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies." Analytica Chimica Acta 1133, no. (2020): 48-57.
Harvard	Akbari Javar H et al. (2020) 'Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies', Analytica Chimica Acta, 1133(), pp. 48-57.
Vancouver	Akbari Javar H, Garkaninejad Z, Dehghannoudeh G, Mahmoudimoghaddam H. Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies. Analytica Chimica Acta. 2020;1133():48-57.
BibTex	@article{ author = {Akbari Javar H and Garkaninejad Z and Dehghannoudeh G and Mahmoudimoghaddam H}, title = {Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies}, journal = {Analytica Chimica Acta}, volume = {1133}, number = {}, pages = {48-57}, year = {2020} }
RIS	TY - JOUR AU - Akbari Javar H AU - Garkaninejad Z AU - Dehghannoudeh G AU - Mahmoudimoghaddam H TI - Development of a New Electrochemical Dna Biosensor Based on Eu3+−Doped Nio for Determination of Amsacrine As an Anti-Cancer Drug: Electrochemical, Spectroscopic and Docking Studies JO - Analytica Chimica Acta VL - 1133 IS - SP - 48 EP - 57 PY - 2020 ER -

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