Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C

Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C

Jokar F¹ ; Vakili MH¹ ; Ghadernejad H² ; Asadifar M³ ; Abdolahpour S⁴ ; Izadi M⁵ ; Moradisardareh H⁴ ; Afrisham R⁴ ; Kooti W⁶

Show Affiliations

1. Department of Chemical Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Iran
2. Medical Student, Hamadan University of Medical Sciences, Hamadan, Iran
3. Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran
4. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
5. Department of Chemical Engineer, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
6. Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Der Pharmacia Lettre Published:2016

Abstract

The main purpose of this studywas preparation of a pharmaceutical formulation with etoposide loaded Poly Butyl Cyano Acrylate (PBCA) nanoparticles and evaluation of its effect on brain cancer. Etoposide loaded nanocarrier was synthesized using micro-emulsion polymerization method and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, BE (2)-C brain cell line was used to determine the rate of nanocarrieretoposide cytotoxicity. Etoposide loaded nanoparticles were characterized and size and zeta potential of nanoparticles containing drugs were measured as 225.3±21.7 nm and -26.3 ±1.5 mv, respectively. Drug loading and encapsulation values were estimated 8.7±0.15 and 97.3±2.1%, respectively. The release amount of drug from PBCA nanoparticles indicated the retention strength corresponding to the formulation. Cytotoxicity studies showed that the cell toxicity effect of drug loaded PBCA nanoparticles is almost two times higher than the free drugs. Finally, it was found that the obtained formulation has a proper stability and drug maintain its stability after storage in 37° for two months. According to the obtained results, this nanoparticle has a potential to be used as a drug delivery system.

Style	Citing Format
MLA	Jokar F, et al.. "Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C." Der Pharmacia Lettre, vol. 8, no. 16, 2016, pp. 96-100.
APA	Jokar F, Vakili MH, Ghadernejad H, Asadifar M, Abdolahpour S, Izadi M, Moradisardareh H, Afrisham R, Kooti W (2016). Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C. Der Pharmacia Lettre, 8(16), 96-100.
Chicago	Jokar F, Vakili MH, Ghadernejad H, Asadifar M, Abdolahpour S, Izadi M, Moradisardareh H, Afrisham R, Kooti W. "Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C." Der Pharmacia Lettre 8, no. 16 (2016): 96-100.
Harvard	Jokar F et al. (2016) 'Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C', Der Pharmacia Lettre, 8(16), pp. 96-100.
Vancouver	Jokar F, Vakili MH, Ghadernejad H, Asadifar M, Abdolahpour S, Izadi M, et al.. Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C. Der Pharmacia Lettre. 2016;8(16):96-100.
BibTex	@article{ author = {Jokar F and Vakili MH and Ghadernejad H and Asadifar M and Abdolahpour S and Izadi M and Moradisardareh H and Afrisham R and Kooti W}, title = {Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C}, journal = {Der Pharmacia Lettre}, volume = {8}, number = {16}, pages = {96-100}, year = {2016} }
RIS	TY - JOUR AU - Jokar F AU - Vakili MH AU - Ghadernejad H AU - Asadifar M AU - Abdolahpour S AU - Izadi M AU - Moradisardareh H AU - Afrisham R AU - Kooti W TI - Preparation of Etoposide Loaded Poly Butyl Cyano Acrylate Nanoparticles and It's Effect on Human Brain Carcinoma Cells Be(2)-C JO - Der Pharmacia Lettre VL - 8 IS - 16 SP - 96 EP - 100 PY - 2016 ER -

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