Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Il-17 and Il-22 Genetic Polymorphisms in Hbv Vaccine Non- and Low-Responders Among Healthcare Workers Publisher



Borzooy Z1, 2 ; Streinucercel A3 ; Mirshafiey A4 ; Khamseh A5 ; Mahmoudie MK5 ; Navabi SS6 ; Nosrati M7 ; Najafi Z8 ; Hosseini M9 ; Jazayeri SM10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  2. 2. Department of Immunology and Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, National Institute of Infectious Diseases ‘Prof. Dr. Matei Bals’, Bucharest, Romania
  4. 4. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Infection Control, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Clinical Virologist, Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: GERMS Published:2016


Abstract

Background Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers. Methods We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms. Results The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p=0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination. Conclusion These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers. © GERMS 2016.
Related Docs
1. Toward Cure Chronic Hepatitis B Infection and Hepatocellular Carcinoma Prevention: Lessons Learned From Nucleos(T)Ide Analogues Therapy, Immunology Letters (2017)
2. Effect of Tetanus-Diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-Responder Individuals, International Journal of Preventive Medicine (2016)
3. Enhanced Th17 Responses in Patients With Autoimmune Hepatitis, Middle East Journal of Digestive Diseases (2019)
4. Identification of Occult Hepatitis B Virus (Hbv) Infection and Viral Antigens in Healthcare Workers Who Presented Low to Moderate Levels of Anti-Hbs After Hbv Vaccination, GERMS (2015)
5. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
6. The Newly Identified T Helper 22 Cells Lodge in Leukemia, International Journal of Hematology-Oncology and Stem Cell Research (2015)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Boroumand (1)
Seyed Mohammad Jazayeri (1)