Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Predictive Markers for Humoral Influenza Vaccine Response in Patients With Common Variable Immunodeficiency Publisher Pubmed



Gardulf A1, 3 ; Abolhassani H1, 3, 7 ; Gustafson R5 ; Eriksson LE2, 4, 6 ; Hammarstrom L1, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
  2. 2. Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden
  3. 3. Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Karolinska University Hospital, Campus Flemingsberg, Stockholm, Sweden
  4. 4. Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
  5. 5. Immunodeficiency Unit, Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
  6. 6. Division of Nursing, School of Health Sciences, City, University of London, London, United Kingdom
  7. 7. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Allergy and Clinical Immunology Published:2018


Abstract

Background: A subgroup of patients with common variable immunodeficiencies (CVIDs) responds to vaccination. The aim of this study was to try to identify predictive markers for those with a humoral immune response after influenza vaccination. Methods: Forty-eight patients with CVID (29 female and 19 male patients; mean age, 57.7 years) were vaccinated with the A(H1N1) influenza vaccine Pandemrix (GlaxoSmithKline, Wavre, Belgium) and boosted after 1 month. Blood samples were collected before each vaccination and 2 months later. Patients with a 4-fold titer increase in results on the hemagglutinin inhibition test (≥1:40) were considered responders and compared with nonresponders for clinical, immunologic, and genetic markers. Results: Eight (16.7%) patients responded to the vaccination. A significantly higher proportion of the responders, who showed a EUROclass SmB−Trnorm21norm profile (P =.03) with a post–germinal center B-cell pattern (P =.04) in blood, experienced enteropathies (P =.04) compared with nonresponders. On the other hand, bronchiectasis was found exclusively among nonresponders (n = 7), as was autoimmune cytopenia (n = 5). Nonresponders with a EUROclass SmB−Trnorm21low profile (P =.02) had a significantly greater prevalence of progressive antibody deficiency (P =.048) and, at diagnosis, a higher mean serum IgM level (P =.03), lower mean serum IgG1 level (P =.007), expansion of absolute counts of cytotoxic CD8+ T cells (P =.033), and increased proportion of memory CD8+ T cells (P =.044) in blood. CVID-associated HLA markers were not detected in responders (P =.03). Conclusion: About one fifth of the patients with CVIDs achieved protective antibody levels after A(H1N1) vaccination and selected clinical, and immunologic markers were identified that might predict a positive outcome of influenza vaccination. Patients with CVID should be offered vaccination also against seasonal influenza because of the potential severity of the infection and risk for bacterial complications. © 2018
Related Docs
View other Related Docs
1. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management, Journal of Investigational Allergology and Clinical Immunology (2020)
2. Autoimmune Disorders Associated With Common Variable Immunodeficiency: Prediction, Diagnosis, and Treatment, Expert Review of Clinical Immunology (2022)
3. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency, International Archives of Allergy and Immunology (2019)
4. Comparison of Various Classifications for Patients With Common Variable Immunodeficiency (Cvid) Using Measurement of B-Cell Subsets, Allergologia et Immunopathologia (2017)
5. Epidemiology and Pathophysiology of Malignancy in Common Variable Immunodeficiency?, Allergologia et Immunopathologia (2017)
6. Histocompatibility Complex Status and Mendelian Randomization Analysis in Unsolved Antibody Deficiency, Frontiers in Immunology (2020)
7. Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed As Common Variable Immunodeficiency, International Reviews of Immunology (2016)
8. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (30)
Laleh Sharifi (7)
Other Related Docs
9. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
10. In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency, Central European Journal of Immunology (2018)
11. The Role of Toll-Like Receptors in B-Cell Development and Immunopathogenesis of Common Variable Immunodeficiency, Expert Review of Clinical Immunology (2016)
12. Primary Antibody Deficiency in a Tertiary Referral Hospital: A 30-Year Experiment, Journal of Investigational Allergology and Clinical Immunology (2015)
13. Clinical Phenotype Classification for Selective Immunoglobulin a Deficiency, Expert Review of Clinical Immunology (2015)
14. Lymphocytes Subsets in Correlation With Clinical Profile in Cvid Patients Without Monogenic Defects, Expert Review of Clinical Immunology (2021)
15. Interleukin-1Β and Interleukin-6 in Common Variable Immunodeficiency and Their Association With Subtypes of B Cells and Response to the Pneumovax-23 Vaccine, European Cytokine Network (2019)
16. A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2017)
17. Decreased Expression of B Cell Maturation Antigen in Patients With Common Variable Immunodeficiency, Pediatric# Allergy# Immunology# and Pulmonology (2017)
18. Primary Immunodeficiencies and Cancers, Cancer Immunology: A Translational Medicine Context (2015)
19. Selective Iga Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Scandinavian Journal of Immunology (2017)
20. Monogenic Mutations Associated With Iga Deficiency, Expert Review of Clinical Immunology (2016)
21. Impaired Akt Phosphorylation in B-Cells of Patients With Common Variable Immunodeficiency, Clinical Immunology (2017)
22. The Profile of Toll-Like Receptor 2 (Tlr2), Tlr4 and Their Cytosolic Downstream Signaling Pathway in Common Variable Immunodeficiency (Cvid) Patients, Iranian Journal of Allergy# Asthma and Immunology (2018)
23. Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management, Expert Review of Clinical Immunology (2017)
24. Revealing Disease Subtypes and Heterogeneity in Common Variable Immunodeficiency Through Transcriptomic Analysis, Scientific Reports (2024)
25. Role of Apoptosis in the Pathogenesis of Common Variable Immunodeficiency (Cvid), Endocrine# Metabolic and Immune Disorders - Drug Targets (2017)
26. T-Cell Abnormalities in Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2016)
27. Evaluation of Radiation Sensitivity in Patients With Hyper Igm Syndrome, Immunological Investigations (2020)
28. Application of Flow Cytometry in Predominantly Antibody Deficiencies, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
29. Inborn Errors of Immunity and Cancers, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
30. Pulmonary Manifestations of Predominantly Antibody Deficiencies, Pulmonary Manifestations of Primary Immunodeficiency Diseases (2018)
31. Evaluation of Effective Factors on Il-10 Signaling in B Cells in Patients With Selective Iga Deficiency, European Cytokine Network (2021)
32. Patients With Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication, Frontiers in Immunology (2017)
33. Phenotyping and Follow up of Forty-Seven Iranian Patients With Common Variable Immunodeficiency, Allergologia et Immunopathologia (2016)
34. Spectrum of Phenotypes Associated With Mutations in Lrba, Journal of Clinical Immunology (2016)
35. Clinical, Immunologic, and Genetic Spectrum of 696 Patients With Combined Immunodeficiency, Journal of Allergy and Clinical Immunology (2018)
36. Autoimmunity in Patients With Selective Iga Deficiency, Journal of Investigational Allergology and Clinical Immunology (2015)
37. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency, Allergy# Asthma and Clinical Immunology (2023)
38. Toward the Stratification and Personalization of Common Variable Immunodeficiency Treatment, Expert Opinion on Orphan Drugs (2016)
39. Measurement of Health-Related Quality of Life in Primary Antibody-Deficient Patients, Immunological Investigations (2017)
40. Mannose-Binding Lectin Protein Deficiency Among Patients With Primary Immunodeficiency Disease Receiving Ivig Therapy, Endocrine# Metabolic and Immune Disorders - Drug Targets (2018)
41. Approach to the Management of Autoimmunity in Primary Immunodeficiency, Scandinavian Journal of Immunology (2017)
42. Rad50 Single-Nucleotide Polymorphism in Predominantly Antibody Deficiency, Journal of Investigational Allergology and Clinical Immunology (2015)
43. B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency, Frontiers in Immunology (2022)
44. Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies, Pediatric Allergy and Immunology (2021)
45. Autoimmunity and Its Association With Regulatory T Cells and B Cell Subsets in Patients With Common Variable Immunodeficiency, Allergologia et Immunopathologia (2018)
46. Immunomodulation of Tlr2 and Tlr4 by G2013 (Α-L-Guluronic Acid) in Cvid Patients, International Journal of Pediatrics (2017)
47. Important Factors Influencing Severity of Common Variable Immunodeficiency, Archives of Iranian Medicine (2016)
48. Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders, Journal of Investigational Allergology and Clinical Immunology (2017)
49. Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia, Journal of Clinical Immunology (2021)
50. G2-Lymphocyte Chromosomal Radiosensitivity in Patients With Lps Responsive Beige-Like Anchor Protein (Lrba) Deficiency, International Journal of Radiation Biology (2019)