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Surveying the Chemical Composition and Antibacterial Activity of Essential Oils From Selected Medicinal Plants Against Human Pathogens



Osanloo M1, 2 ; Ghaznavi G3 ; Abdollahi A4
Authors
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Authors Affiliations
  1. 1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  4. 4. Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: Iranian Journal of Microbiology Published:2020

Abstract

Background and Objectives: Essential oils (EOs) with different biological activities, such as antibacterial properties, are a valuable resource for developing new drugs. Materials and Methods: Ingredients of six medicinally important EOs, including Artemisia dracunculus, Anethum graveolens, Citrus limon, Citrus sinensis, Cinnamomum zeylanicum and Zingiber officinale, were identified using GC-MS analysis. Moreover, their five major compounds were also listed. Furthermore, the half-maximal inhibitory concentration (IC50) against four important human bacteria was also investigated using the 96-well plate microdilution. Results: C. sinensis EO with IC50 of 1.0 and 4.7 mg.mL-1 have the most effect on the growth of S. aureus and P. aeruginosa. Moreover, EOs of Cinnamomum zeylanicum (IC50: 1.0 mg. mL-1) and Artemisia dracunculus (IC50: 1.3 mg.mL-1) significantly showed better inhibitory effect on E. coli and K. pneumoniae. Conclusion: These EOs could be used for developing inexpensive, potent, and green antibacterial agents. © 2020, Tehran University of Medical Sciences. All rights reserved.
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