Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway

Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway Publisher Pubmed

Soukhtanloo M¹ ; Mohtashami E² ; Maghrouni A³ ; Mollazadeh H⁴ ; Mousavi SH⁵ ; Roshan MK¹ ; Tabatabaeizadeh SA⁶ ; Hosseini A² ; Vahedi MM⁷ ; Jalilinik M¹ ; Afshari AR⁴

Source: Pharmacological Reports Published:2020

Abstract

Background: Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to current medical interventions, particularly chemo/radiation. Hence, it necessitates further therapeutic options that could enhance the efficacy of existing modalities. Methods: A comprehensive and systematic review of literature on the NF-κB signaling pathway-contributed in the pathogenesis of GBM with a focus on natural products was carried out. Results: Several examinations have shown that nuclear factor (NF)-κB is participated in apoptosis, cellular proliferation, angiogenesis, metastasis, invasion, and many other processes implicated in GBM pathobiology. Recent studies have provided that NF-κB regulation is the primary pharmacological target for GBM therapy. Specific natural products are involved in several signaling pathways implicated in tumor growth and apoptosis of GBM cells. Conclusion: In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences.

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Style	Citing Format
MLA	Soukhtanloo M, et al.. "Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway." Pharmacological Reports, vol. 72, no. 2, 2020, pp. 285-295.
APA	Soukhtanloo M, Mohtashami E, Maghrouni A, Mollazadeh H, Mousavi SH, Roshan MK, Tabatabaeizadeh SA, Hosseini A, Vahedi MM, Jalilinik M, Afshari AR (2020). Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway. Pharmacological Reports, 72(2), 285-295.
Chicago	Soukhtanloo M, Mohtashami E, Maghrouni A, Mollazadeh H, Mousavi SH, Roshan MK, Tabatabaeizadeh SA, et al.. "Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway." Pharmacological Reports 72, no. 2 (2020): 285-295.
Harvard	Soukhtanloo M et al. (2020) 'Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway', Pharmacological Reports, 72(2), pp. 285-295.
Vancouver	Soukhtanloo M, Mohtashami E, Maghrouni A, Mollazadeh H, Mousavi SH, Roshan MK, et al.. Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway. Pharmacological Reports. 2020;72(2):285-295.
BibTex	@article{ author = {Soukhtanloo M and Mohtashami E and Maghrouni A and Mollazadeh H and Mousavi SH and Roshan MK and Tabatabaeizadeh SA and Hosseini A and Vahedi MM and Jalilinik M and Afshari AR}, title = {Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway}, journal = {Pharmacological Reports}, volume = {72}, number = {2}, pages = {285-295}, year = {2020} }
RIS	TY - JOUR AU - Soukhtanloo M AU - Mohtashami E AU - Maghrouni A AU - Mollazadeh H AU - Mousavi SH AU - Roshan MK AU - Tabatabaeizadeh SA AU - Hosseini A AU - Vahedi MM AU - Jalilinik M AU - Afshari AR TI - Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway JO - Pharmacological Reports VL - 72 IS - 2 SP - 285 EP - 295 PY - 2020 ER -

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