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Differential Expression of Cancer Stem Cell Markers Aldh1 and Cd133 in Various Lung Cancer Subtypes Publisher Pubmed



Roudi R1, 2, 3 ; Korourian A1 ; Shariftabrizi A4 ; Madjd Z1, 2, 3
Authors
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Authors Affiliations
  1. 1. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Oncopathology Research Center, Iran University of Medical Sciences, Hemmat Street (Highway), Next to Milad Tower, Tehran, 14496-14530, Iran
  4. 4. Department of Nuclear Medicine and Molecular Imaging, State University of New York at Buffalo, Buffalo, NY, United States

Source: Cancer Investigation Published:2015


Abstract

Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression. Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. ALDH1 and CD133 had higher expression levels in the NSCLC compared to the SCLC. Over-expression of both ALDH1 and CD133 markers was exclusively found in SCC and ADC. Low level of ALDH1 expression was strongly correlated with poor differentiation in ADC cases. Thus, ALDH1high/CD133high phenotype can be considered as a CSC marker in some lung cancer subtypes. © 2015 Informa Healthcare USA, Inc.
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