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Gut Microbiota and Serum Biomarker Analyses in Obese Patients Diagnosed With Diabetes and Hypothyroid Disorder Publisher Pubmed



Tabasi M1, 2 ; Eybpoosh S3 ; Sadeghpour Heravi F4 ; Siadat SD5 ; Mousavian G6 ; Elyasinia F7 ; Soroush A8 ; Bouzari S1
Authors
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Authors Affiliations
  1. 1. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Surgical Infection Research Group, Faculty of Medicine and Health Science, Macquarie University, Sydney, Australia
  5. 5. Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
  6. 6. HIV/STI Surveillance Research Center, And WHO Collaborating Center for HIV Surveillance Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Metabolic Syndrome and Related Disorders Published:2021


Abstract

Background: Variations of serum biomarkers and bacterial diversity of the gastrointestinal tract in obese patients with diabetes or hypothyroid are poorly understood. The aim of this study was to provide recent findings in this regard. Methods: A total of 119 obese patients [17 with diabetes, 23 with hypothyroid, and 79 patients without either diabetes or hypothyroid (control)] were recruited in this study. Serum biomarkers such as biochemical, hormonal (insulin and glucagon), and cytokine levels [interleukin (IL)-6, IL-1β, tumor necrosis factor-alpha, IL-10, and transforming growth factor beta-1 (TGF-β1)] were measured under fasting conditions. Bacterial abundance of gut microbiota was also quantitated by real-time polymerase chain reaction using 16S rRNA gene-based specific primers. Results: Average value of blood sugar (P: 0.0184), hemoglobin A1c, insulin, homeostasis model assessment insulin resistance, TGF-β 1, IL-6, IL-1β, interferon gamma (Pfor each < 0.001), and phylum Actinobacteria [odds ratio (OR): 1.5, P: 0.032] was significantly higher in diabetic versus control group. In contrast, the levels of IL-10 (P < 0.001), Firmicutes (OR: 0.6, P: 0.058), and Akkermansia muciniphila (OR: 0.4, P: 0.053) were significantly lower in diabetic versus control group. However, there was no statistically significant difference between the values in hypothyroid versus control group either in crude or adjusted models. Conclusion: While there are some relationships between serum biomarkers or bacterial abundance with diabetes prediction in obese patients, this prognostication is less likely in obese patients with hypothyroid. Further investigation is warranted in the application of identified preclinical biomarkers in the diagnosis of diabetes or hypothyroid in obese patients. © Copyright 2021, Mary Ann Liebert, Inc., publishers.
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