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Carbon-Based Biosensors From Graphene Family to Carbon Dots: A Viewpoint in Cancer Detection Publisher Pubmed



Safari M1 ; Moghaddam A2 ; Salehi Moghaddam A3 ; Absalan M4 ; Kruppke B5 ; Ruckdaschel H6 ; Khonakdar HA2, 5
Authors
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Authors Affiliations
  1. 1. Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Iran Polymer and Petrochemical Institute, Tehran, Iran
  3. 3. Department of Bioengineering, Lehigh University, Bethlehem, 18015, PA, United States
  4. 4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran
  5. 5. Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universitat Dresden, Dresden, 01069, Germany
  6. 6. Department of Polymer Engineering, University of Bayreuth, Bayreuth, Germany

Source: Talanta Published:2023


Abstract

According to the latest report by International Agency for Research on Cancer, 19.3 million new cancer cases and 10 million cancer deaths were globally reported in 2020. Early diagnosis can reduce these numbers significantly, and biosensors have appeared to be a solution to this problem as, unlike the traditional methods, they have low cost, rapid process, and do not need experts present on site for use. These devices have been incorporated to detect many cancer biomarkers and measure cancer drug delivery. To design these biosensors, a researcher must know about their different types, properties of nanomaterials, and cancer biomarkers. Among all types of biosensors, electrochemical and optical biosensors are the most sensitive and promising sensors for detecting complicated diseases like cancer. The carbon-based nanomaterial family has attracted lots of attention due to their low cost, easy preparation, biocompatibility, and significant electrochemical and optical properties. In this review, we have discussed the application of graphene and its derivatives, carbon nanotubes (CNTs), carbon dots (CDs), and fullerene (C60), for designing different electrochemical and optical cancer-detecting biosensors. Furthermore, the application of these carbon-based biosensors for detecting seven widely studied cancer biomarkers (HER2, CEA, CA125, VEGF, PSA, Alpha-fetoprotein, and miRNA21) is reviewed. Finally, various fabricated carbon-based biosensors for detecting cancer biomarkers and anticancer drugs are comprehensively summarized as well. © 2023
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