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Protein Corona: Opportunities and Challenges Publisher Pubmed



Zanganeh S1 ; Spitler R1 ; Erfanzadeh M2 ; Alkilany AM3 ; Mahmoudi M4
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, CA, United States
  2. 2. Department of Biomedical Engineering, University of Connecticut, Storrs, 06269, CT, United States
  3. 3. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, 11942, Jordan
  4. 4. Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Biochemistry and Cell Biology Published:2016


Abstract

In contact with biological fluids diverse type of biomolecules (e.g., proteins) adsorb onto nanoparticles forming protein corona. Surface properties of the coated nanoparticles, in terms of type and amount of associated proteins, dictate their interactions with biological systems and thus biological fate, therapeutic efficiency and toxicity. In this perspective, we will focus on the recent advances and pitfalls in the protein corona field. © 2016 Elsevier Ltd.
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