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Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona Publisher Pubmed



Saha K1 ; Rahimi M2, 3 ; Yazdani M1 ; Kim ST1 ; Moyano DF1 ; Hou S1 ; Das R1 ; Mout R1 ; Rezaee F4 ; Mahmoudi M5, 6 ; Rotello VM1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, 01003, MA, United States
  2. 2. Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, Netherlands
  3. 3. Lehrstuhl fur Biotechnologie, RWTH Aachen University, Worringerweg 3, Aachen, 52074, Germany
  4. 4. University Medical Center Groningen (UMCG), University of Groningen, Groningen, 9713 AV, Netherlands
  5. 5. Nanotechnology Research Center, Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
  6. 6. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States

Source: ACS Nano Published:2016


Abstract

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages. © 2016 American Chemical Society.
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