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Lower Serum Levels of Meteorin-Like/Subfatin in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus Are Negatively Associated With Insulin Resistance and Inflammatory Cytokines Publisher Pubmed



Dadmanesh M1 ; Aghajani H2 ; Fadaei R3 ; Ghorban K4
Authors
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Authors Affiliations
  1. 1. Department of Infectious Diseases, School of Medicine, Aja University of Medical Sciences, Tehran, IR, Iran
  2. 2. Interventional Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IR, Iran
  3. 3. Department of Biochemistry, School of Medicine, Aja University of Medical Sciences, Tehran, IR, Iran
  4. 4. Department of Immunology, School of Medicine, Aja University of Medical Sciences, Tehran, IR, Iran

Source: PLoS ONE Published:2018


Abstract

Meteorin-like (Metrnl) is a newly discovered adipokine with favorable effect on insulin sensitivity. Previous studies have reported lower levels of Metrnl in obese patients. However, there is conflicting data regarding its circulating levels in type 2 diabetes mellitus (T2DM) and there is no data in patients with coronary artery disease (CAD). The aim of the present study was to evaluate the Metrnl serum level in patients with T2DM and CAD, and also to evaluate the serum levels of Metrnl with serum levels of adiponectin, IL-6 and TNF-α in patients. This study was conducted on 66 patients with CAD, 63 T2DM patients and 41 controls. The serum levels of Metrnl, adiponectin, IL-6 and TNF-α were measured using ELISA techniques. The serum levels of Metrnl were found to be lower in CAD (75.18 ± 28.48 pg/ mL) and T2DM patients (73.89 ± 33.60 pg/mL) compared to the control group (95.33 ± 32.56 pg/mL) (p < 0.005 and p<0.003, respectively). Additionally, adiponectin decreased in CAD and T2DM patients as compared to the control group, while IL-6 and TNF-α were higher in CAD and T2DM patients. Metrnl showed independent association with the risk of CAD and T2DM presence. Furthermore, Metrnl illustrated a negative correlation with IL-6 and TNF-α in both CAD patients and also with BMI, insulin resistance, IL-6 and TNF-α in T2DM patients. Metrnl showed an association with CAD and T2DM presence and with components of their pathogenesis such as inflammation and insulin resistance. These results suggested a possible interaction between Metrnl and the pathogenesis of CAD and T2DM, however more studies are needed to prove this concept. © 2018 Dadmanesh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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