Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Serum Galectin-3 Level in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Publisher Pubmed



M Mahalleh MEHRDAD ; Ah Behnoush Amir HOSSEIN ; A Khalaji AMIRMOHAMMAD ; M Gouravani MAHDI ; R Assempoor RAMIN ; Ar Jamshidi Ahmad REZA ; Mt Mahmoudi Mahdi T ; E Farhadi ELHAM
Authors

Source: Iranian Journal of Allergy, Asthma and Immunology Published:2024


Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial tissue transformation and fibroblast-like synoviocyte (FLS) proliferation. Galectin-3 is gaining attention as a diagnostic and prognostic biomarker for RA diagnosis. Elevated levels of Galectin-3 cause RA-FLSs to stimulate and generate proinflammatory agents, contributing to cartilage degradation and osteoclast formation. This systematic review and meta-analysis aimed to evaluate published evidence and support future investigation of Galectin-3 as an early biomarker for RA. A systematic search was performed through four databases, including PubMed, the Web of Science, Scopus, and Embase, to find the studies examining Galectin-3 in individuals with RA compared to healthy controls. The risk of bias was evaluated using the Newcastle-Ottawa Quality Assessment Scale. Random-effects meta-analysis comparing serum/plasma Galectin-3 levels between individuals with RA and healthy control groups was performed to determine the standardized mean differences (SMD) along with 95% confidence intervals. Following the initial search, studies went through screening. 12 studies, involving 773 patients with RA and 411 healthy controls, were included. Meta-analysis of the included studies revealed that individuals with RA had significantly higher levels of circulatory Galectin-3 compared to healthy control groups (SMD 0.957, 95% CI 0.393 to 1.520). Univariable meta-regression showed no significant association between age, publication year, sample size, or the male percentage with effect size. According to the results, Galectin-3 might be useful as a biomarker for RA. To support these findings, further investigations of Galectin-3 as a possible early biomarker of RA is necessary. © 2024 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Role of Galectin-3 As a Biomarker in Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Sleep and Breathing (2023)
2. Galectins Can Serve As Biomarkers in Covid-19: A Comprehensive Systematic Review and Meta-Analysis, Frontiers in Immunology (2023)
3. The Impact of Anti-Tnf-Α Therapy on Leptin and Inflammatory Markers in Rheumatoid Arthritis Patients: A Case-Control Study, BMC Rheumatology (2025)
Experts (# of related papers)
View all Related Experts
Mahdi Mahmoudi (7)
Ahmad Reza Jamshidi (6)
Other Related Docs
4. Nf-Κb Signaling in Rheumatoid Arthritis With Focus on Fibroblast-Like Synoviocytes, Autoimmunity Highlights (2020)
5. The Role of Β-D-Mannuronic Acid, As a New Non-Steroidal Anti-Inflammatory Drug on Expression of Mir-146A, Irak1, Traf6, Nf-Κb and Pro-Inflammatory Cytokines Following a Clinical Trial in Rheumatoid Arthritis Patients, Immunopharmacology and Immunotoxicology (2020)
6. A Mechanistic Review on Medicinal Plants Used for Rheumatoid Arthritis in Traditional Persian Medicine, Journal of Pharmacy and Pharmacology (2016)
7. Association Between Dietary Inflammatory Index Scores and the Increased Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study, Nutrition Journal (2022)
8. Effectiveness of Combination of Leflunomide and Methotrexate Compared to Etanercept in the Treatment of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis, Health Technology Assessment in Action (2020)
9. Are Genetic Variations in Il-21–Il-23R–Il-17A Cytokine Axis Involved in a Pathogenic Pathway of Rheumatoid Arthritis? Bayesian Hierarchical Meta-Analysis, Journal of Cellular Physiology (2019)
10. Safety, Tolerability, and Efficacy of Tocilizumab in Rheumatoid Arthritis: An Open-Label Phase 4 Study in Patients From the Middle East, International Journal of Rheumatology (2015)
11. The Effect of Human Recombinant Tumor Necrosis Factor Receptor-2 on Reducing Inflammatory of Collagen -Induced Arthritis in Balb/C Mice, Iranian Journal of Biotechnology (2019)
12. Quantitation of Cd4+/Cd25+/High/Cd127low/- Regulatory T-Cells in Rheumatoid Arthritis Patients, Iranian Journal of Immunology (2021)
13. Anti-Inflammatory Effects of Prima-1Met (Mutant P53 Reactivator) Induced by Inhibition of Nuclear Factor-Κb on Rheumatoid Arthritis Fibroblast-Like Synoviocytes, Inflammopharmacology (2023)
14. Role of Fibroblast Activation Protein Alpha in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis, Iranian Journal of Allergy# Asthma and Immunology (2021)
15. The Signal Transducer and Activator of Transcription Factors Lodge in Immunopathogenesis of Rheumatoid Arthritis, Reumatismo (2015)
16. Advanced Glycation End Products, Advanced Oxidation Protein Products, and Ferric Reducing Ability of Plasma in Patients With Rheumatoid Arthritis: A Focus on Activity Scores, Clinical Rheumatology (2021)
17. The Role of the Cx3cl1/Cx3cr1 Axis As Potential Inflammatory Biomarkers in Subjects With Periodontitis and Rheumatoid Arthritis: A Systematic Review, Immunity# Inflammation and Disease (2024)
18. Transformation of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis; From a Friend to Foe, Autoimmunity Highlights (2021)
19. The Effect of Disease-Modifying Antirheumatic Drugs (Dmards) on Bone Homeostasis in Rheumatoid Arthritis (Ra) Patients, Inflammopharmacology (2023)
20. Tak-242 (Resatorvid) Inhibits Proinflammatory Cytokine Production Through the Inhibition of Nf-Κb Signaling Pathway in Fibroblast-Like Synoviocytes in Osteoarthritis Patients, Advances in Rheumatology (2024)