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Vitamin D Receptor Gene Polymorphisms in Iranian Azary Patients With Behcet's Disease Publisher Pubmed



Kolahi S1 ; Khabbazi A1 ; Khodadadi H2 ; Estiar M3 ; Hajialiloo M4 ; Emrahi L5 ; Sakhinia E5, 6
Authors
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Authors Affiliations
  1. 1. Connective Tissue Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  3. 3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Medical Genetics, Faculty of Medicine and Tabriz Genetic Analysis Centre (TGAC), Tabriz University of Medical Sciences, Tabriz, Iran

Source: Scandinavian Journal of Rheumatology Published:2015


Abstract

Objectives: The aim of our study was to investigate the association of four polymorphisms of the VDR gene (FokI, BsmI, TaqI, and ApaI) with their susceptibility to Behcet's disease (BD) and their clinical manifestations with respect to the Iranian Azari population. Method: In this cross-sectional study we considered the BsmI, FokI, ApaI, and TaqI polymorphisms in 50 Iranian Azary patients with BD and 50 healthy controls, with the use of polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). Results: A significant difference was found for the FokI polymorphism between the case and control groups. The f allele frequency of 26% was present in BD patients, compared to only 13% in the control group. In addition, the f/f genotype was significantly associated with BD. We found no significant differences between the BD and control groups regarding the distribution of ApaI, BsmI, and TaqI genotype frequencies. We found no association between VDR polymorphisms and the clinical manifestations of BD. Conclusions: The VDR f allele and f/f genotype are associated with BD in the Iranian Azari population. © 2015 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
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