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Role of Regulatory T Cells in Pathogenesis and Therapeutics of Hashimoto’S Thyroiditis Publisher



E Asadollahzadeh ELNAZ ; Z Ebadi ZAHRA ; Z Hamed ZAHRA ; An Moghadasi Abdorreza NASER
Authors

Source: Published:2024


Abstract

Hashimoto's thyroiditis (HT) is a common autoimmune disease that affects the thyroid gland. Regulatory T cells (Tregs) have been identified as key players in controlling autoimmunity. The majority of the included studies reported a decrease in Tregs in HT patients compared to healthy controls. Furthermore, Treg therapy was found to be effective in ameliorating autoimmune HT in animal models. However, there were discrepancies in the results regarding the effect of Tregs on HT in humans. Some studies reported a positive effect, while others did not observe any significant effect. Further studies with larger sample sizes and better-designed protocols are needed to establish the effect of Tregs on autoimmune HT. In conclusion, Tregs have been shown to play a crucial role in the regulation of autoimmunity in HT. Treg therapy could be a promising approach for the treatment of autoimmune HT, although more research is needed to confirm its efficacy. © 2024 Elsevier B.V., All rights reserved.
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