Tehran University of Medical Sciences

Science Communicator Platform

Share By
Role of Regulatory T Cells in Pathogenesis and Therapeutics of Hashimoto’S Thyroiditis Publisher



E Asadollahzadeh ELNAZ ; Z Ebadi ZAHRA ; Z Hamed ZAHRA ; An Moghadasi Abdorreza NASER
Authors

Source: Published:2024


Abstract

Hashimoto's thyroiditis (HT) is a common autoimmune disease that affects the thyroid gland. Regulatory T cells (Tregs) have been identified as key players in controlling autoimmunity. The majority of the included studies reported a decrease in Tregs in HT patients compared to healthy controls. Furthermore, Treg therapy was found to be effective in ameliorating autoimmune HT in animal models. However, there were discrepancies in the results regarding the effect of Tregs on HT in humans. Some studies reported a positive effect, while others did not observe any significant effect. Further studies with larger sample sizes and better-designed protocols are needed to establish the effect of Tregs on autoimmune HT. In conclusion, Tregs have been shown to play a crucial role in the regulation of autoimmunity in HT. Treg therapy could be a promising approach for the treatment of autoimmune HT, although more research is needed to confirm its efficacy. © 2024 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. The Role of T Regulatory Cells in Immunopathogenesis of Myasthenia Gravis: Implications for Therapeutics, Expert Review of Clinical Immunology (2015)
2. The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities, Frontiers in Immunology (2021)
3. Thymol As a Reciprocal Regulator of T Cell Differentiation: Promotion of Regulatory T Cells and Suppression of Th1/Th17 Cells, International Immunopharmacology (2019)
Experts (# of related papers)
View all Related Experts
Ali Akbar Amirzargar (2)
Amir Ali Hamidieh (2)
Other Related Docs
4. Isolation and in Vitro Expansion of Regulatory T Cells From Β-Thalassemia Major Kids and in Vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines, International Archives of Allergy and Immunology (2023)
5. Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes, Iranian Journal of Immunology (2015)
6. The Frequency of Cd4+ T Cells in Women With Hashimoto's Thyroiditis, International Journal of Endocrinology and Metabolism (2021)
7. Directed Differentiation of Regulatory T Cells From Naive T Cells and Prevention of Their Inflammation-Mediated Instability Using Small Molecules, Clinical and Experimental Immunology (2020)
8. Identification, Isolation, and Functional Assay of Regulatory T Cells, Immunological Investigations (2016)
9. Immunometabolism Crosstalk Between Regulatory T Cells and Glucose Homeostasis of Type 1 Diabetes, Clinical and Experimental Immunology (2026)
10. Tregs in Allogeneic Hematopoietic Stem Cell Transplantation: Suppressing Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia, Transplantation and Cellular Therapy (2026)
11. The Association of Elevated Plasma Cortisol and Hashimoto’S Thyroiditis, a Neglected Part of Immune Response, Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine (2016)