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Lipidomics-Driven Drug Discovery and Delivery Strategies in Glioblastoma Publisher Pubmed



Weng X1 ; Gonzalez M1 ; Angelia J1 ; Piroozmand S2 ; Jamehdor S3 ; Behrooz AB4 ; Latifinavid H2, 5, 6 ; Ahmadi M7 ; Pecic S1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry and Biochemistry, California State University Fullerton, Fullerton, 92831, CA, United States
  2. 2. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  3. 3. Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Department of Human Anatomy and Cell Sciences, University of Manitoba, Max Rady College of Medicine, Winnipeg, MB, Canada
  5. 5. School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  6. 6. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Iran
  7. 7. Department of Analytical Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran

Source: Biochimica et Biophysica Acta - Molecular Basis of Disease Published:2025


Abstract

With few viable treatment options, glioblastoma (GBM) is still one of the most aggressive and deadly types of brain cancer. Recent developments in lipidomics have demonstrated the potential of lipid metabolism as a therapeutic target in GBM. The thorough examination of lipids in biological systems, or lipidomics, is essential to comprehending the changed lipid profiles found in GBM, which are linked to the tumor's ability to grow, survive, and resist treatment. The use of lipidomics in drug delivery and discovery is examined in this study, focusing on how it may be used to find new biomarkers, create multi-target directed ligands, and improve drug delivery systems. We also cover the use of FDA-approved medications, clinical trials that use lipid-targeted medicines, and the integration of lipidomics with other omics technologies. This study emphasizes lipidomics as a possible tool in developing more effective treatment methods for GBM by exploring various lipid-centric techniques. © 2024 The Author(s)
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