Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis and Activity Evaluation of New Benzofuran-1,3,4-Oxadiazole Hybrids Against Wood-Degrading Fungi Publisher



Hosseinihashemi SK1 ; Toolabi M2 ; Abedinifar F3 ; Moghimi S3 ; Jalaligoldeh A4 ; Paknejad F5 ; Arabahmadi S6 ; Foroumadi A2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Wood Science and Paper Technology, Karaj Branch, Islamic Azad University, Karaj, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Horticulture Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran
  5. 5. Department of Agronomy and Plant Breeding, Karaj Branch, Islamic Azad University, Karaj, Iran
  6. 6. Department of Chemistry, University of Mazandaran, P. O. Box: 47416-95447, Babolsar, Iran

Source: BioResources Published:2020


Abstract

A series of novel benzofuran-1,3,4-oxadiazole hybrids were synthesized and evaluated as antifungal agents. The synthetic pathway was started from salicylaldehyde, which afforded 5-(substituted benzylthio)-1,3,4-oxadiazole derivatives in moderate to good yields. The compounds were investigated for their antifungal potential against white-rot, Trametes versicolor and brown-rot, Poria placenta and Coniophora puteana fungi at different concentrations (500, 1000 ppm). The obtaining results demonstrated that most of the compounds at 500 ppm concentration did not exhibit acceptable antifungal effects but they had better antifungal activity at 1000 ppm concentration. Compounds 5a, 5c, and 5i showed inhibition percentages of 14.6%, 23.0%, and 14.7%, against the growth of P. placenta and C. puteana, respectively. Among the compounds, the 2-(benzofuran-2-yl)-5-(2,6-difluorobenzyl)thio)-1,3,4-oxadiazole (5h) hybrid was the most active one. © 2020, North Carolina State University.
Related Docs
1. Design and Synthesis of Benzodiazepine-1,2,3-Triazole Hybrid Derivatives As Selective Butyrylcholinesterase Inhibitors, Molecular Diversity (2020)
2. 6-Cinnamoyl-4-Arylaminothienopyrimidines As Highly Potent Cytotoxic Agents: Design, Synthesis and Structure-Activity Relationship Studies, European Journal of Medicinal Chemistry (2020)
3. Design, Synthesis, and Biological Evaluation of 1-(5-(Benzylthio)-1,3,4-Thiadiazol-2-Yl)-3-Phenylurea Derivatives As Anticancer Agents, Medicinal Chemistry Research (2020)
4. Synthesis and Cholinesterase Inhibitory Activity of New 2-Benzofuran Carboxamide-Benzylpyridinum Salts, Bioorganic Chemistry (2018)
5. Design and Synthesis of New Benzofuran-1,2,3-Triazole Hybrid Preservatives and the Evaluation of Their Antifungal Potential Against White and Brown-Rot Fungi, BioResources (2020)
6. Thiazole in the Targeted Anticancer Drug Discovery, Future Medicinal Chemistry (2019)
Experts (# of related papers)
View all Related Experts
Alireza Foroumadi (5)
Loghman Firoozpour (3)