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Equisetum Arvense and Nano Zinc Oxide-Infused Polycaprolactone Scaffolds: A Multifaceted Approach for Antibacterial, Antioxidant, and Hemocompatible Wound Dressing Publisher



Chinijani TH1 ; Afza S1 ; Yousefiasl S2 ; Manoochehri H3 ; Pourmotabed S4 ; Arabestani M5, 6 ; Makvandi P7, 8, 9 ; Sharifi E10, 11, 12 ; Esfahani H1
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Bu-Ali Sina University, Hamedan, Iran
  2. 2. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  4. 4. Department of Emergency Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Infectious Disease Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China
  8. 8. Centre of Research Impact and Outreach, Chitkara University, Rajpura, India
  9. 9. Department of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai, India
  10. 10. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  11. 11. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  12. 12. Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Polymer Engineering and Science Published:2024


Abstract

An appropriate skin tissue-engineered scaffold can act promptly to combat microbial infection and preserve the wound throughout all phases of healing. To achieve sufficient healing, scaffolds should also promote cell proliferation and regeneration. Therefore, it has become essential to develop skin tissue engineering scaffolds that mimic the extracellular matrices of the skin, provide a high porosity scaffold structure, and act as an antimicrobial protection during wound healing. In this study, the polycaprolactone (PCL) electrospun scaffold was modified with optimal amounts of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) herbal extract for potential application as antibacterial and wound healing scaffolds. Full characterization was carried out for fabricated scaffolds before in-vitro assessments. FTIR spectroscopy and SEM images verified the successful substitution of nanofibers with EA and ZnO. These substitutions increased the hydrophilicity compared to the PCL scaffold. According to the results, the PCL/ZnO/EA fabricated scaffold was hemocompatible and non-cytotoxic, in addition to allowing proper cell attachment. Effective antibacterial efficiency against Gram-positive and Gram-negative bacteria was also observed in this sample. Finally, the in vitro wound healing assay indicated that the addition of ZnO and EA improves the wound healing capacity of the scaffolds. The results indicate the potential of the developed scaffolds to prevent wound contamination and the complications of chronic infection. Highlights: Optimal concentrations of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) were incorporated into electrospun polycaprolactone (PCL) nanofibers for potential wound dressing applications. The fabricated nanofibrous wound dressings offer a multitude of structural features in biomaterials. PCL fibers enable the controlled release of both ZnO and EA. The fabricated scaffolds exhibit favorable antibacterial, and antioxidant properties while maintaining biocompatibility and hemocompatibility. © 2024 Society of Plastics Engineers.
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