Electrochemical Determination of Gliclazide on Magnetic Coreshell Fe3o4@Sio2 Functionalized Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode Publisher



Ganjali MR^{1, 2} ; Salimi H³ ; Tajik S⁴ ; Beitollahi H⁴ ; Badiei A^{5, 6} ; Ziarani GM⁷
Source: International Journal of Electrochemical Science Published:2017

Abstract

The report covers the construction of a novel modified glassy carbon electrode (GCE), using magnetic core-shell Fe3O4@SiO2 and multi-walled carbon nanotubes (MWCNTs). The resulting device was then tested as a tool for the sensitive and selective analysis of traces of gliclazide (GLZ). The effects of different parameters, i.e. pH of the test solution, and the scan rate applied during the electrochemical determination process on the performance of the resulting electrode were also assessed. The results obtained under the optimal conditions showed the response of the electrode to gliclazide to be linear over a rather wide range of 5.0 × 10-6 to 8.0 × 10-4 M, and a detection limit of as low as 2.1 × 10-6 M (pH=7.0). The proposed sensor was successfully applied for the determination of gliclazide in real samples. © 2017 The Authors.