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Coulometric Differential Fft Admittance Voltammetry Determination of Amlodipine in Pharmaceutical Formulation by Nano-Composite Electrode Publisher Pubmed



Norouzi P1 ; Gupta VK2 ; Larijani B3 ; Rasoolipour S4 ; Faridbod F1, 5 ; Ganjali MR1, 5
Authors
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  2. 2. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India
  3. 3. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Institute of Petroleum Industry (RIPI), Tehran, Iran
  5. 5. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Talanta Published:2015


Abstract

An electrochemical detection technique based on combination of was coulometric differential fast Fourier transformation admittance voltammetry (CDFFTAV) and nano-composite film modified glassy carbon electrode was successfully applied for sensitive determination of Amlodipine. The nano-composite film was made by a mixture of ionic liquid, 1-ethyl-3- methylimidazolium tetrafluoroborate (EMIMBF4), multiwall carbon nanotube and Au nanoparticles as electrochemical mediators. Studies reveal that the irreversible oxidation of Amlodipine was highly facile on the electrode surface. The electrochemical response was established on calculation of the charge under the admittance peak, which was obtained by discrete integration of the admittance response in a selected potential range, obtained in a flow injection analysis. Once established the best operative optimum conditions, the resulting nano-composite film electrode showed a catalytic effect on the oxidation of the analyte. The response is linear in the Amlodipine concentration range of 1.0×10-9 to 2.0×10-7 M with a detection limit of 1.25×10-10 M. Moreover, the proposed technique exhibited high sensitivity, fast response time (less than 6 s) and long-term stability and reproducibility around 96%, and it was successfully used to the determination of Amlodipine content in the pharmaceutical formulation. © 2014 Elsevier B.V.