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Association Between Empirically Derived Nutrient Patterns and Breast Cancer: A Case–Control Study in a Middle Eastern Country Publisher



Dehghani F5 ; Sasanfar B1, 3, 4, 9 ; Toorang F4, 5, 8 ; Zendehdel K4, 6, 7 ; Salehiabargouei A1, 2, 3
Authors
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Authors Affiliations
  1. 1. Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, P O Box 8915173160, Yazd, Iran
  4. 4. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, P.O.Box 13145158, Tehran, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Breast Diseases Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Departments of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  9. 9. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: BMC Nutrition Published:2024


Abstract

Purpose: The risk of breast cancer (BC) and related mortality have increased in Middle-East countries during recent decades. The relationship between several nutrient intakes and the risk of BC has been investigated in several studies. However, few studies have estimated the effects of patterns of different nutrient intake on the risk of BC in this region. Methods: A total of 453 patients who were recently diagnosed with breast cancer and 516 healthy women participated in the current case–control study. To evaluate the dietary intakes, we used a validated 168-item food frequency questionnaire (FFQ) during the last year. Nutrient Patterns (NPs) were extracted through factor analysis (FA) of energy-adjusted twenty-six nutrients. The relationship between nutrient patterns and the risk of breast cancer in pre and post-menopausal women was estimated by multivariable regression. Results: Four major nutrient patterns were identified in the current study. The first nutrient pattern was rich in animal protein, retinol, riboflavin, pantothenic acid, cobalamin, and calcium. Higher saturated fatty acids (SFAs), mono-unsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and trans fatty acids (TFAs), and lower intakes of niacin were observed in nutrient pattern 2. The third nutrient pattern was rich in fiber, potassium, and vitamin C. Nutrient pattern 4, was associated with higher intakes of vegetable protein, alpha-tocopherol, and magnesium. A significant inverse relationship was observed between adherence to nutrient pattern 3 and the risk of BC in all participants [odds ratio (OR) = 0.70, 95% confidence interval (CI): 0.50, 0.97, P = 0.03) and pre-menopausal women (OR = 0.59 (0.39–0.89), P = 0.01). Conclusion: Decreasing odds of breast cancer were observed by adherence to a nutrient pattern high in dietary fiber, vitamin C, and potassium. Future prospective investigations are recommended to confirm these findings. © The Author(s) 2024.
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