Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity

Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity Publisher

Vosooghi M¹ ; Farzipour S¹ ; Saeedi M^{2, 3} ; Shareh NB¹ ; Mahdavi M¹ ; Mahernia S¹ ; Foroumadi A¹ ; Amanlou M¹ ; Shafiee A¹

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, 14176, Tehran, Iran
2. Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Iranian Chemical Society Published:2015

Abstract

Abstract A simple and practical method is described for the synthesis of novel 5-arylidene derivatives of barbituric and thiobarbituric acid. 2-Formylbenzoic acids reacted easily with (thio)barbituric acids in the presence of p-toluenesulfonic acid (p-TsOH) in MeOH/EtOH to obtain the title compound in good yields. Then, their urease inhibitory activity were evaluated in vitro and compared with hydroxyurea as the reference drug. © 2015 Iranian Chemical Society.

Style	Citing Format
MLA	Vosooghi M, et al.. "Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity." Journal of the Iranian Chemical Society, vol. 12, no. 8, 2015, pp. 1487-1491.
APA	Vosooghi M, Farzipour S, Saeedi M, Shareh NB, Mahdavi M, Mahernia S, Foroumadi A, Amanlou M, Shafiee A (2015). Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity. Journal of the Iranian Chemical Society, 12(8), 1487-1491.
Chicago	Vosooghi M, Farzipour S, Saeedi M, Shareh NB, Mahdavi M, Mahernia S, Foroumadi A, Amanlou M, Shafiee A. "Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity." Journal of the Iranian Chemical Society 12, no. 8 (2015): 1487-1491.
Harvard	Vosooghi M et al. (2015) 'Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity', Journal of the Iranian Chemical Society, 12(8), pp. 1487-1491.
Vancouver	Vosooghi M, Farzipour S, Saeedi M, Shareh NB, Mahdavi M, Mahernia S, et al.. Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity. Journal of the Iranian Chemical Society. 2015;12(8):1487-1491.
BibTex	@article{ author = {Vosooghi M and Farzipour S and Saeedi M and Shareh NB and Mahdavi M and Mahernia S and Foroumadi A and Amanlou M and Shafiee A}, title = {Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity}, journal = {Journal of the Iranian Chemical Society}, volume = {12}, number = {8}, pages = {1487-1491}, year = {2015} }
RIS	TY - JOUR AU - Vosooghi M AU - Farzipour S AU - Saeedi M AU - Shareh NB AU - Mahdavi M AU - Mahernia S AU - Foroumadi A AU - Amanlou M AU - Shafiee A TI - Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity JO - Journal of the Iranian Chemical Society VL - 12 IS - 8 SP - 1487 EP - 1491 PY - 2015 ER -

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