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Synthesis and Cytotoxicity of Novel Chromenone Derivatives Bearing 4-Nitrophenoxy Phenyl Acryloyl Moiety Publisher



Mahdavi M1, 2 ; Mohammadiizad S1 ; Saeedi M3, 4 ; Safavi M5 ; Ebrahimi SES1 ; Foroumadi A2 ; Shafiee A2
Authors
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Authors Affiliations
  1. 1. School of Pharmacy, International Campus (TUMS-IC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biotechnology, Iranian Research Organization for Science and Technology, P. O. Box 3353-5111, Tehran, Iran

Source: Journal of the Iranian Chemical Society Published:2016


Abstract

This work describes synthesis of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety through the reaction of 4-(4-nitrophenoxy)benzaldehydes and 3-acetyl-2H-chromen-2-ones in refluxing toluene. Cytotoxicity of all compounds was evaluated using a tetrazolium (MTT) colorimetric assay against human breast cancer cell line, MDA-MB-231. © 2016, Iranian Chemical Society.