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Evaluation of Rocen on Burn Wound Healing and Thermal Pain: Transforming Growth Factor-Β1 Activation Publisher Pubmed



Goudarzi R1 ; Nasab ME2 ; Saffari PM2 ; Zamanian G2 ; Park CD3 ; Partoazar A2, 4
Authors
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Authors Affiliations
  1. 1. Division of Research and Development, Pharmin USA, LLC, San Jose, CA, United States
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Pharmacy, Sungkyunkwan University, Seoul, South Korea
  4. 4. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Lower Extremity Wounds Published:2021


Abstract

The present study aimed to evaluate the effect of liposomal arthrocen 2% (ROCEN) on the healing of burn wound and pain alleviation of thermal stimuli in a rat model of the second-degree burn. The results showed that ROCEN formulation significantly improved the main parameters of burn wound healing in a short period of time (7 days). The percentage of wound surface was also reduced significantly compared with the control group following once daily application of ROCEN for 14 days. The level of TGF (transforming growth factor)-β1 cytokine was also elevated significantly in the burn tissue treated with ROCEN almost the same as zinc oxide cream. Also, ROCEN showed a significant analgesic effect evaluated by 2 models of acute thermal pain, tail-flick and hotplate tests, which suggested that the formulation may act as a pain reliever in burn injuries. In conclusion, the application of the topical formulation of ROCEN may have benefits in the acceleration of the wound healing process and alleviation of the pain due to burn injuries. © The Author(s) 2020.
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