Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of the Effect of Adipocyte-Derived Stem Cells and Curcumin Nanoliposomes With Phenytoin on Open Cutaneous Wound Healing in Rats Publisher Pubmed



Ebrahimzade M1 ; Mirdoraghi M2 ; Alikarami A1 ; Heidari S1 ; Rastegar T1 ; Partoazar AR3 ; Takzaree N1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Radiology and Radiotherapy, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2021


Abstract

Background: Reducing the healing time of wounds can decrease the patient's immobility time and their medical costs, leading a faster return of the patients to daily work. Objective: The aim of the present study is to compare the effect of adipose-derived stem cells and cur-cumin-containing liposomal nanoparticles with phenytoin on wound healing. Methods: After anesthesia of the rats, open skin ulcers were made by a bistoury blade. Subsequently, stem cells were removed from the adipose tissue of the upper border of the epididymis. The originality of stem cells was then confirmed by the flow cytometry. The fusion method was used to prepare the liposome; and also, nanoliposomal particles were confirmed by using the DLS microscope. The percentage of recovery and the cell count was measured with IMAGEJ. The expression of genes was assessed by PCR. The number of fibroblasts was counted by immunohistochemistry techniques. The amount of collagen was determined by Tri-chromosome staining, and the number of capillaries was enumerated by H & E staining. Results: The expression of the TGF-β1 gene, vascular number, wound healing rate and the number of fibroblasts increased significantly in adipose tissue-derived stem cells and curcumin nanoliposome groups (p<0.05); the wound surface was also decreased significantly (p<0.05). Conclusion: Based on the results of our research, adipose tissue-derived stem cells and curcumin nanoliposomes can heal wounds efficiently. © 2021 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Adipose Tissue-Derived Stromal Cells for Wound Healing, Advances in Experimental Medicine and Biology (2018)
2. Injectable Multifunctional Hydrogel Based on Carboxymethylcellulose/Polyacrylamide/Polydopamine Containing Vitamin C and Curcumin Promoted Full-Thickness Burn Regeneration, International Journal of Biological Macromolecules (2023)
3. Therapeutic Applications of Turmeric and Its Principle Constituent Curcumin in Wound Healing and Skin Regeneration From the Perspective of Conventional Medicine and Iranian Traditional Medicine (Itm), Journal of Medicinal Plants (2018)
4. Investigating Histopathologic the Synergistic Effect of Topical Use of Mentha Pulegium Essential Oil and Honey in Healing of Cutaneous Ulcers, Journal of Medicinal Plants (2020)
5. Curcumin in Tissue Engineering: A Traditional Remedy for Modern Medicine, BioFactors (2019)
6. Localized Delivery of Healing Stimulator Medicines for Enhanced Wound Treatment, Journal of Drug Delivery Science and Technology (2024)
7. Efficacy of a Natural Topical Skin Ointment for Managing Split-Thickness Skin Graft Donor Sites: A Pilot Double-Blind Randomized Controlled Trial, Advances in Skin and Wound Care (2020)
8. The Exosomes Released From Different Cell Types and Their Effects in Wound Healing, Journal of Cellular Biochemistry (2018)
Experts (# of related papers)
View all Related Experts
Alireza Partoazar (6)
Mohammad Abdollahi (2)
Other Related Docs
9. Angiogenic Effects of Low-Intensity Cathodal Direct Current on Ischemic Diabetic Foot Ulcersa Randomized Controlled Trial, Diabetes Research and Clinical Practice (2017)
10. Wound Healing Effects of Curcumin: A Short Review, Current Pharmaceutical Biotechnology (2016)
11. Bio-Guided Fractionation and Isolation of Active Component From Tragopogon Graminifolius Based on Its Wound Healing Property, Journal of Ethnopharmacology (2018)
12. New Concepts in Wound Targeting Through Liposome-Based Nanocarriers (Lbns), Journal of Drug Delivery Science and Technology (2022)
13. Phosphatidylserine Liposomes Containing Curcumin Inhibit Bone Loss in Osteoporotic Rats: A Possible Synergy Through a Common Signaling Pathway, Journal of Food Biochemistry (2022)
14. Enhanced Healing of a Full-Thickness Wound by a Thermoresponsive Dressing Utilized for Simultaneous Transfer and Protection of Adipose-Derived Mesenchymal Stem Cells Sheet, Journal of Materials Science: Materials in Medicine (2020)
15. Bioinspired Nanotechnologies for Skin Regeneration, Nanoscience in Dermatology (2016)
16. Adipose-Derived Stem Cells: Potentials, Availability and Market Size in Regenerative Medicine, Current Stem Cell Research and Therapy (2023)
17. In Vitro Antioxidant Activity and in Vivo Wound-Healing Effect of Lecithin Liposomes: A Comparative Study, Journal of Comparative Effectiveness Research (2019)
18. Evaluation of Rocen on Burn Wound Healing and Thermal Pain: Transforming Growth Factor-Β1 Activation, International Journal of Lower Extremity Wounds (2021)
19. Natural Product-Based Nanomedicines for Wound Healing Purposes: Therapeutic Targets and Drug Delivery Systems, International Journal of Nanomedicine (2018)
20. Estimation of Anti-Inflammatory and Analgesic Effects of Topical Nanocen (Nanoliposomal Arthrocen) on Mice, AAPS PharmSciTech (2019)