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Evaluation of Propylene Glycol Nanoliposomes Containing Curcumin on Burn Wound Model in Rat: Biocompatibility, Wound Healing, and Anti-Bacterial Effects Publisher Pubmed



Kianvash N1 ; Bahador A2 ; Pourhajibagher M3 ; Ghafari H4 ; Nikoui V5 ; Rezayat SM4, 6 ; Dehpour AR4, 6 ; Partoazar A6
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Keshavarz Blvd, 100 Poursina Ave, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Dental Implant Research Center, Dentistry Research Institute, Laser Research Center of Dentistry (LRCD), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Drug Delivery and Translational Research Published:2017


Abstract

Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior. TEM analysis of nanocarriers showed no aggregation in long time storage up to 60 days. The biocompatibility of the Cur-PgL formulation was evaluated by ISO standards. We found that Cur-PgL 0.3% was the effective dose in injured rats without any side effects on intact skin. The cytotoxicity of the Cur-PgL 0.3% nanovesicles was also assessed on human dermal fibroblast (HDF) cells. The results showed no detectable cytotoxicity, but considerable cytotoxicity was observed in higher concentration of 1.5 and 3 mg/ml of free and PgL forms of curcumin. Eight days of application of Cur-PgL on burned rats resulted in a significant (P<0.001) recovery of wound repair parameters, and after 18 days, wound contraction occurred significantly (P < 0.001) compared to the other groups. The antibacterial activity of the Cur-PgL formulation was found to be similar to the silver sulfadiazine (SSD) cream 1% regarding the inhibition of the bacterial growth. In conclusion, the low dose of curcumin nanoliposomal formulation efficiently improved injuries and infections of burn wounds and it can be considered in burn therapy. © 2017, Controlled Release Society.