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Genetic Analysis of the Znf512b, Slc41a1, and Aldh2 Polymorphisms in Parkinson's Disease in the Iranian Population Publisher Pubmed



Madadi F1 ; Khaniani MS2 ; Shandiz EE3 ; Ayromlou H4 ; Najmi S4 ; Emamalizadeh B5 ; Taghavi S5 ; Jamshidi J6 ; Tafakhori A7 ; Shahidi GA8 ; Darvish H5
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, 5166615573, Iran
  3. 3. Neurology Department, Ganjavian Hospital, Dezful University of Medical Sciences, Dezful, Iran
  4. 4. Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
  6. 6. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  7. 7. Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran, University of Medical Sciences, Tehran, Iran
  8. 8. Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Genetic Testing and Molecular Biomarkers Published:2016


Abstract

Aims: Parkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population. Methods: In a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PD patients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests. Results: A significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95% CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms. Conclusion: The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population. © Copyright 2016, Mary Ann Liebert, Inc.
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