Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population

Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population Publisher Pubmed

Zarrabi Alhosseini M¹ ; Jamshidi J² ; Zare Bidoki A³ ; Ganji S⁴ ; Eslami Amirabadi MR⁵ ; Emamalizadeh B⁶ ; Taghavi S⁶ ; Shokraeian P⁷ ; Mohajerani F⁸ ; Darvish H⁶

Show Affiliations

1. Faculty of Basic Sciences, Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
3. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Mehr Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
5. Department of Psychiatry, Imam Hossein Medical Hospital, Shahid Behashti University of Medical Sciences, Tehran, Iran
6. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
8. Advanced Science & Technology Faculty, Tehran Medical Branch, Islamic Azad University, Tehran, Iran

Source: Neurological Research Published:2016

Abstract

Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD. Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6–16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6–16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped. Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD. Discussion: To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

2. A Genetic Variant in Camkk2 Gene Is Possibly Associated With Increased Risk of Bipolar Disorder, Journal of Neural Transmission (2016)

3. Association Analysis of Disc1 Gene Polymorphisms With Attention-Deficit Hyperactivity Disorder in Iranian Population, Pakistan Journal of Medical Sciences (2015)

4. Sipa1l2, Mir4697, Gch1 and Vps13c Loci and Risk of Parkinson's Diseases in Iranian Population: A Case-Control Study, Journal of the Neurological Sciences (2016)

Experts (# of related papers)

Abbas Tafakhori (1)

Mahdi Zamani (1)

Style	Citing Format
MLA	Zarrabi Alhosseini M, et al.. "Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population." Neurological Research, vol. 38, no. 11, 2016, pp. 959-964.
APA	Zarrabi Alhosseini M, Jamshidi J, Zare Bidoki A, Ganji S, Eslami Amirabadi MR, Emamalizadeh B, Taghavi S, Shokraeian P, Mohajerani F, Darvish H (2016). Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population. Neurological Research, 38(11), 959-964.
Chicago	Zarrabi Alhosseini M, Jamshidi J, Zare Bidoki A, Ganji S, Eslami Amirabadi MR, Emamalizadeh B, Taghavi S, Shokraeian P, Mohajerani F, Darvish H. "Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population." Neurological Research 38, no. 11 (2016): 959-964.
Harvard	Zarrabi Alhosseini M et al. (2016) 'Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population', Neurological Research, 38(11), pp. 959-964.
Vancouver	Zarrabi Alhosseini M, Jamshidi J, Zare Bidoki A, Ganji S, Eslami Amirabadi MR, Emamalizadeh B, et al.. Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population. Neurological Research. 2016;38(11):959-964.
BibTex	@article{ author = {Zarrabi Alhosseini M and Jamshidi J and Zare Bidoki A and Ganji S and Eslami Amirabadi MR and Emamalizadeh B and Taghavi S and Shokraeian P and Mohajerani F and Darvish H}, title = {Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population}, journal = {Neurological Research}, volume = {38}, number = {11}, pages = {959-964}, year = {2016} }
RIS	TY - JOUR AU - Zarrabi Alhosseini M AU - Jamshidi J AU - Zare Bidoki A AU - Ganji S AU - Eslami Amirabadi MR AU - Emamalizadeh B AU - Taghavi S AU - Shokraeian P AU - Mohajerani F AU - Darvish H TI - Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population JO - Neurological Research VL - 38 IS - 11 SP - 959 EP - 964 PY - 2016 ER -

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