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Cerebral Venous Sinus Thrombosis Associated With Sars-Cov-2; a Multinational Case Series Publisher Pubmed



Mowla A1 ; Shakibajahromi B2 ; Shahjouei S3 ; Borhanihaghighi A2 ; Rahimian N4 ; Baharvahdat H5 ; Naderi S6 ; Khorvash F7 ; Altafi D8 ; Ebrahimzadeh SA9 ; Farahmand G10 ; Vaghefi Far A10 ; Sharma VK11 ; Neshin SAS12 Show All Authors
Authors
  1. Mowla A1
  2. Shakibajahromi B2
  3. Shahjouei S3
  4. Borhanihaghighi A2
  5. Rahimian N4
  6. Baharvahdat H5
  7. Naderi S6
  8. Khorvash F7
  9. Altafi D8
  10. Ebrahimzadeh SA9
  11. Farahmand G10
  12. Vaghefi Far A10
  13. Sharma VK11
  14. Neshin SAS12
  15. Tsivgoulis G13, 14
  16. Zand R3, 14

Source: Journal of the Neurological Sciences Published:2020


Abstract

Background: SARS-CoV-2 induced coagulopathy can lead to thrombotic complications such as stroke. Cerebral venous sinus thrombosis (CVST) is a less common type of stroke which might be triggered by COVID-19. We present a series of CVST cases with SARS-CoV-2 infection. Methods: In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012–2016 from the country where the majority of cases were recruited. Results: A total of 13 patients fulfilled the inclusion criteria (62% women, mean age 50.9 ± 11.2 years). Six patients were discharged with good outcomes (mRS ≤ 2) and three patients died in hospital. Compared to the control group, the SARS-CoV-2 infected patients were significantly older (50.9 versus 36.7 years, p < 0.001), had a lower rate of identified CVST risk factors (23.1% versus 84.2%, p < 0.001), had more frequent cortical vein involvement (38.5% versus 10.5%, p: 0.025), and a non-significant higher rate of in-hospital mortality (23.1% versus 5.3%, p: 0.073). Conclusion: CVST should be considered as potential comorbidity in SARS-CoV-2 infected patients presenting with neurological symptoms. Our data suggest that compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS-CoV-2 infected group. © 2020
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