The Effects of Guar Gum Supplementation on Glycemic Control, Body Mass and Blood Pressure in Adults: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Javad Alaeian M¹ ; Pourreza S² ; Yousefi M¹ ; Golalipour E¹ ; Setayesh L³ ; Zeinali Khosroshahi M⁴ ; Bagheri R⁵ ; Ashtarylarky D⁶ ; Wong A⁷ ; Zamani M⁸ ; Asbaghi O^{9, 10} Show Affiliations
Source: Diabetes Research and Clinical Practice Published:2023

Abstract

Background: This systematic review and meta-analysis sought to evaluate the effects of guar gum supplementation on glycemic control, blood pressure, and body mass in adults. Methods: Relevant studies were obtained by searching the PubMed, SCOPUS, Embase, and Web of Science databases (from inception to January 2022). Weighted mean differences (WMD) and 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. Results: Pooled analysis of 14 randomized controlled trials (RCTs) revealed that guar gum supplementation led to significant reductions in hemoglobin A1c (HbA1c) (WMD: −0.47 mg/dL, 95% CI: −0.75, −0.18, p = 0.001). However, there was no effect on fasting blood sugar (FBS), systolic and diastolic blood pressure, and body mass among adults in comparison with the control group. A subgroup analysis demonstrated that intervention in patients with type 2 diabetes (T2DM), and high supplementation dosages (>15 g/d) significantly decreased FBS concentrations, but not in other subgroups. Conclusion: Guar gum supplementation may yield a beneficial effect on glycemic control in T2DM patients. However, the extant clinical trials, thus far, are not sufficient enough to form guidelines for clinical practice. © 2023 Elsevier B.V.