The Effects of Gymnema Sylvestre Supplementation on Lipid Profile, Glycemic Control, Blood Pressure, and Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis Publisher Pubmed



Zamani M¹ ; Ashtarylarky D² ; Nosratabadi S³ ; Bagheri R⁴ ; Wong A⁵ ; Rafiei MM^{6, 7} ; Asiabar MM⁸ ; Khalili P⁹ ; Asbaghi O¹⁰ ; Davoodi SH^{10, 11} Show Affiliations
Source: Phytotherapy Research Published:2023

Abstract

There is a growing interest in the considerable health benefits of Gymnema Sylvestre (GS) supplementation, as some studies have reported that it may improve cardiometabolic risk factors. However, the widespread impact of GS supplementation on the parameters mentioned above is not fully resolved. Consequently, this study aimed to examine the effects of GS supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults. Eligible randomized controlled trials (RCT), published up to November 2021, were identified through PubMed, Scopus, and ISI Web of Science databases. Six studies were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). All studies were conducted in adults that used a GC supplement (>1 week) and assessed our selected cardiovascular risk factors. Outcomes revealed that GS supplementation significantly decreased triglyceride (p <.001), total cholesterol (p <.001), low-density lipoprotein (p <.001), fasting blood sugar (p <.001), and diastolic blood pressure (p =.003). Some limitations, including notable heterogeneity, low quality of studies, and lack of diversity among research participants, should be considered when interpreting our results. Our outcomes suggest that GS supplementation may improve cardiovascular risk factors. Future large-high-quality RCTs with longer duration and various populations are needed to firmly establish the clinical efficacy of the plant. © 2022 John Wiley & Sons Ltd.