Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers

Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers Publisher

Arjmand B¹ ; Razzaghi M² ; Tavirani MR³ ; Rostaminejad M⁴ ; Tavirani MR³ ; Vafaee R^{2, 6}

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1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
6. Critical Care Quality Improvement Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2022

Abstract

Aim: The current study aimed to determine the common dysregulated proteins between esophageal, gastric, and intestinal cancers. Background: Though there are several documents about the role of AKT1 in promoting of esophageal, gastric, and intestinal cancers, there is not enough evidence about the dominant role of AKT1 relative to the other oncogene genes in the promotion of the three studied cancer types. Methods: One hundred proteins related to each of esophageal, gastric, or intestinal cancer were retrieved from the STRING database and interacted by Cytoscape software v 3.2.7. 2 to create the correlated interactomes. The network was analyzed by the NetworkAnalyzerapplication of Cytoscape to find the centrality parameters of the nodes. Results of network analysis and action map assessment were used to determine the common critical proteins between the three studied cancers. Results One hundred proteins were extracted for each of the studied cancers. Among 42 common dysregulated proteins, 36 individuals were selected through network analysis and were screened through action map assessment. Eighteen proteins were introduced as the important common proteins. Finally, AKT1 was a candidate for the crucial dysregulated proteins common in the three analyzed diseases. Conclusion: The findings indicate that AKT1, relative to the other oncogene genes, is a suitable candidate to be evaluated in patients as a prediagnostic tool to reduce endoscopy and colonoscopy rates. © 2022 RIGLD.

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Babak Arjmand (1)

Style	Citing Format
MLA	Arjmand B, et al.. "Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers." Gastroenterology and Hepatology from Bed to Bench, vol. 15, no. 1, 2022, pp. 87-92.
APA	Arjmand B, Razzaghi M, Tavirani MR, Rostaminejad M, Tavirani MR, Vafaee R (2022). Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers. Gastroenterology and Hepatology from Bed to Bench, 15(1), 87-92.
Chicago	Arjmand B, Razzaghi M, Tavirani MR, Rostaminejad M, Tavirani MR, Vafaee R. "Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers." Gastroenterology and Hepatology from Bed to Bench 15, no. 1 (2022): 87-92.
Harvard	Arjmand B et al. (2022) 'Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers', Gastroenterology and Hepatology from Bed to Bench, 15(1), pp. 87-92.
Vancouver	Arjmand B, Razzaghi M, Tavirani MR, Rostaminejad M, Tavirani MR, Vafaee R. Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers. Gastroenterology and Hepatology from Bed to Bench. 2022;15(1):87-92.
BibTex	@article{ author = {Arjmand B and Razzaghi M and Tavirani MR and Rostaminejad M and Tavirani MR and Vafaee R}, title = {Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers}, journal = {Gastroenterology and Hepatology from Bed to Bench}, volume = {15}, number = {1}, pages = {87-92}, year = {2022} }
RIS	TY - JOUR AU - Arjmand B AU - Razzaghi M AU - Tavirani MR AU - Rostaminejad M AU - Tavirani MR AU - Vafaee R TI - Introducing Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers JO - Gastroenterology and Hepatology from Bed to Bench VL - 15 IS - 1 SP - 87 EP - 92 PY - 2022 ER -

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