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Synthesis of Novel Dibenzylbutyrolactones As Dimethylmatairesinol Analogues Publisher



Heidary Alizadeh B1 ; Foroumadi A2, 3 ; Kobarfard F4 ; Saeedi M2 ; Shafiee A2
Authors
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Authors Affiliations
  1. 1. Iranian Research Institute of Plant Protection (IRIPP), Shahid Chamran Avenue, Yaman St. No 1, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
  3. 3. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
  4. 4. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2015


Abstract

In this work, (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one was prepared though an efficient and novel method starting from (S)-5-((benzyloxy)methyl)dihydrofuran-2(3H)-one. Then, it was utilized as a versatile starting material for the synthesis of novel dimethylmatairesinol analogues; dibenzylbutyrolactone derivatives, via the reaction of the later compound and various aromatic aldehydes. © 2014 HeteroCorporation.