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One-Pot Reaction of 3-Vinylchromones, Aromatic Aldehydes, and Ammonium Acetate: An Efficient Approach to Highly Functionalized 1,6-Dihydropyridine Derivatives Publisher



Farajpour B1 ; Kakaie M1 ; Hussain FHS2 ; Rakaee F1 ; Moradkhani F3 ; Shiri M1
Authors

Source: RSC Advances Published:2025


Abstract

In this work, we present an efficient strategy for the straightforward synthesis of functionalized 1,6-dihydropyridine derivatives via a three-component reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate. A tandem procedure including in situ NH aldimine formation/Michael-type addition/opening of the pyrone ring/isomerization/6π-electrocyclization/[1,5]-H shift allows rapid access to a series of dihydropyridines bearing an ortho-hydroxybenzoyl and a benzoyl scaffold in good yields. Readily available precursors, simple heating conditions, and operational simplicity are some highlighted advantages of this transformation. © 2025 The Royal Society of Chemistry.
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