Surgical Management of Gingival Plasma Cell Granuloma With Histopathological and Immunohistochemical Confirmation Through Cd138 and Kappa/Lambda Polyclonally: A Case Report Publisher



Alarcon Sanchez M A ; Martinez Gonzalez E J ; Gonzalez Alvarez G E ; Olivos Navarro E F ; Robles Garcia M A ; Escoto Vasquez L S ; Heboyan A ; Lomeli Martinez S M
Source: Journal of Surgical Case Reports Published:2026

Abstract

Plasma cell granuloma (PCG) is a benign inflammatory lesion of reactive origin that is rarely found in the oral cavity. Accurate recognition is essential to differentiate it from malignant lesions and avoid overtreatment or unnecessary radical resections. We present the case of a 26-year-old female with no systemic history who presented with an asymptomatic, firm, erythematous gingival mass in the right upper posterior sextant. The lesion was associated with subgingival dental calculus and a deep carious lesion involving the first premolar and first molar. Treatment included complete surgical excision, extraction of both teeth, and bone curettage. Histopathological examination confirmed PCG, while immunohistochemistry showed CD138 positivity (70%) and polyclonal Kappa/Lambda expression, excluding monoclonal neoplastic restriction. At the 2-month follow-up, healing was satisfactory without recurrence. Histopathological and immunohistochemical evaluation provides a definitive diagnosis, and conservative surgical management is curative. © The Author(s) 2026. Published by Oxford University Press and JSCR Publishing Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.