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Role of Resveratrol in Modulating Micrornas in Human Diseases: From Cancer to Inflammatory Disorder Publisher Pubmed



Amiri A1 ; Mahjoubintehran M1, 2 ; Asemi Z3 ; Shafiee A4 ; Hajighadimi S4 ; Moradizarmehri S4 ; Mirzaei HR5 ; Mirzaei H3
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada
  5. 5. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Medicinal Chemistry Published:2021


Abstract

Cancer and inflammatory disorders are two important public health issues worldwide with significant socio-economic impacts. Despite several efforts, the current therapeutic platforms are associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural compounds could be used either alone or in combination with the standard cancer therapeutic modalities such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound that is found in grapes as well as other foods. It has been found that this medicinal agent displays a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic effects by targeting various cellular and molecular mechanisms. Among cellular and molecular targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in many processes that are involved in the initiation and progression of cancer and inflammatory disorders. Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in cancer and inflammatory disorders. © 2021 Bentham Science Publishers.
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