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Comparison of Estimated Human Effective Dose of 67Ga- and 99Mtc-Labeled Bombesin Based on Distribution Data in Mice Publisher



Shanehsazzadeh S1 ; Lahooti A2 ; Shirmardi SP3, 4 ; Erfani M1
Authors
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Authors Affiliations
  1. 1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O.Box:11365-3486, Tehran, Iran
  2. 2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Central Iran Research Complex (Yazd), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  4. 4. Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2015


Abstract

This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN. © 2015, Akademiai Kiado, Budapest, Hungary.
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