Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
The Effects of 6% Hydroxyethyl Starch Compared With Normal Saline on Controlling Undesirable Hemodynamic Changes Following Spinal Anesthesia in Patients Undergoing Orthopedic Surgery: A Randomized Clinical Trial Publisher



Yaghobi S1 ; Alirezaei AH2 ; Bakhtiyari M3, 4 ; Khezri MB1 ; Massoudi N5
Authors

Source: Journal of Cellular and Molecular Anesthesia Published:2017


Abstract

Background: The aim of the current study was to compare the effects of normal saline solution and 6% hydroxyethyl starch (HES/HAES) solution on hemodynamic changes after spinal anesthesia in patients undergoing lower limb orthopedic surgery. Materials and Methods: This randomized clinical trial was performed on 50 patients undergoing surgery, aged 20-60, with physical status of ASA I, II. Before surgery, the hemodynamic status of each patient including systolic and diastolic blood pressure, heart rate, and central venous pressure was measured. Then, the patients were randomly divided into two groups and for the control group, 7 ml/kg 9% (or normal) saline and for the experimental group 6% hydroxyethyl starch were administered. Hemodynamic indices were re-measured after the completion of infusion, and then spinal anesthesia was performed. After anesthesia, hemodynamic indices were measured every 5 minutes for 1 hour and then every 10 minutes for 2 hours. The analysis of variance (ANOVA) for repeated measures was used to evaluate the significant changes in hemodynamic indices. Results: The mean and standard deviation of systolic and diastolic blood pressure, heart rate, and central venous pressure in the control group were 113.0 (7.3), 73.0 (6.0), 95.6 (5.7), and 5.8 (0.9), respectively, and in the intervention group were 104.8 (5.5), 66.1 (4.2), 95.8 (8.2), and 4.3 (0.9(. ANOVA for repeated measures showed that the incidence of decreasing changes in systolic and diastolic blood pressure, heart rate, and central venous pressure of the patients for whom hydroxyethyl starch was prescribed was significantly less than that of the patients for whom normal saline was prescribed. Conclusion: Hydroxyethyl starch has a more effective role in controlling hemodynamic changes before spinal anesthesia than normal saline. © 2017 Shahid Beheshti University of Medical Sciences, Anesthesiology Research Center. All rights reserved.
Related Docs
View other Related Docs
1. Accessing the Efficacy and Peri-Operative Adverse Effects of Three Different Hyperbaric Bupivacaine 0.5% Dosages for Spinal Anesthesia Induction in Lower Limb Orthopedic Surgeries: A Randomized Clinical Trial, BMC Anesthesiology (2024)
2. Prevalence of Abnormal Methemoglobinemia and Its Determinants in Patients Receiving Nitroglycerin During Anesthesia, Anesthesiology and Pain Medicine (2019)
3. Comparing the Hemodynamic Effects of Intravenous and Volatile Anesthesia in Patients With End Stage Renal Disease Undergoing Laparoscopic Implantation of Peritoneal Dialysis Catheter in a Randomized Double-Blind Clinical Trial, Archives of Anesthesiology and Critical Care (2024)
Experts (# of related papers)
View all Related Experts
Mehdi Sanatkar (4)
Farhad Etezadi (4)
Other Related Docs
4. Comparison of the Analgesic Effects of a Mixture of Lidocaine and Epinephrin With Those of a Mixture of Lidocaine and Bicarbonate for Local Anesthesia, International Journal of Pharmacy and Technology (2016)
5. Spinal Anesthesia and Spinal Anesthesia With Subdiaphragmatic Lidocaine in Shoulder Pain Reduction for Gynecological Laparoscopic Surgery: A Randomized Clinical Trial, Pain Research and Management (2017)
6. Ketamine or Atropine: Which One Better Prevents Oculocardiac Reflex During Eye Surgery? a Prospective Randomized Clinical Trial, Acta Medica Iranica (2015)
7. Blood Glucose Dynamics in Diabetic Patients Undergoing Elective Surgery: A Descriptive-Analytical Cross-Sectional Investigation, Archives of Anesthesiology and Critical Care (2024)
8. The Comparison of Infusion of Two Different Sedation Regimens With Propofol and Ketamine Combination During Plastic and Reconstructive Surgery, Aesthetic Plastic Surgery (2015)
9. The Effects of Acupuncture on Hemodynamic Changes During Endotracheal Intubation for General Anesthesia, Medical Acupuncture (2019)
10. A Comparative Study on the Use of Ketamine and Apotel Infusion Pump for the Control of Pain After Posterior Fusion Operations: A Randomized Controlled Trial, Shiraz E Medical Journal (2020)
11. Evaluation of Spinal Anesthesia Blockade Time With 0.5% Hyperbaric Bupivacaine, With or Without Sufentanil, in Chronic Opioid Users: A Randomized Clinical Trial; [Avaliacao Do Tempo De Bloqueio Da Raquianestesia Com Bupivacaina a Hiperbarica 0,5%, Com Ou Sem Sufentanil, Em Usuarios Cronicos De Opioides: Um Estudo Clinico Randomico], Brazilian Journal of Anesthesiology (2016)
12. The Efficacy of Intrathecal Methyl-Prednisolone for Acute Spinal Cord Injury: A Pilot Study, Heliyon (2023)
13. The Effect of Mannitol and Hypertonic Sodium Administration on Hemodynamic Parameters Under Lidco Monitoring in Patients Undergoing Elective Craniotomy, Acta Medica Iranica (2023)
14. The Efficacy of Intraoperative Ketamine-Haloperidol for Prevention of Catheter-Related Bladder Discomfort After Lumbar Spinal Stenosis Surgery, Oman Medical Journal (2019)
15. Spinal Anesthesia for Outpatients' Surgeries, Archives of Anesthesiology and Critical Care (2023)
16. Effects of Ultrasound-Guided Supraclavicular Block Using Bupivacaine-Dexmedetomidine or Bupivacaine Alone in Hemodynamics of Patients Undergoing Upper Limb Orthopedic Surgery, Acta Medica Iranica (2022)
17. Double-Blind, Randomized, Controlled Pilot Trial to Specify Collateral Effect and Safety of Perioperative Dexmedetomidine in Patients Undergoing Open Heart Surgery, Anesthesiology and Pain Medicine (2025)
18. Comparison of Effectiveness and Safety of Labetalol and Hydralazine on Blood Pressure During Cataract Surgery in Patients With Hypertension, Revista Latinoamericana de Hipertension (2019)
19. Comparative Assessment of the Effects of Hydroxyethyl Starch and Normal Saline on Severe Hypotension in Patients With Aluminum Phosphide Poisoning: A Retrospective Study, Journal of Toxicology (2022)
20. The Effect of Digital Nerve Block on the Accuracy of Hemoglobin Monitoring During Surgery: A Randomized Clinical Trial, Acta Anaesthesiologica Belgica (2021)