Bioinformatics Analysis of Ronin Gene and Their Potential Role in Pluripotency Control Publisher



Ziaei S^{1, 2} ; Ardeshirylajimi A³ ; Arefian E⁴ ; Enderami SE⁵ ; Soleimani M⁶ ; Rezaeitavirani M² Show Affiliations
Source: Gene Reports Published:2018

Abstract

Pluripotent stem cells are essential cells because of their potential roles in regenerative medicine. In order to produce induced pluripotent stem cells from adult cells, we need to know more about the pluripotency genes. In this study, we analyzed the Ronin as one of the important pluripotency genes by Bioinformatics approaches. The Ronin is belonging to THAP supper family and sequence analysis shows that the THAP domain region in Ronin is highly conservative and the phylogenetic analysis shows that the Ronin is conserved from fish to mammals. Gene expression analysis shows that the expression of Ronin in differentiated tissues is negligible and there is a meaningful change during differentiation and embryo developments. In this article, we analyzed the human Ronin structure, evolutionary relations and its expression in distinct conditions. We are believed that this could be helpful to understanding the stemness procedure and could be a light for further researches. © 2018