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Stem Cell-Based Approach for the Treatment of Parkinson's Disease



Goodarzi P1 ; Aghayan HR2 ; Larijani B3 ; Soleimani M4 ; Dehpour AR5 ; Sahebjam M6 ; Ghaderi F6 ; Arjmand B7
Authors
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Authors Affiliations
  1. 1. Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Chronic Diseases Research Center, Endocrinology and Metabolism Research Institute and Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical sciences, Tehran, Iran
  4. 4. Hematology Department, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. GMP-Compliant Stem Cell Facility, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute and Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Shariati Hospital, North Kargar, Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2015

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative brain disorder which is around 1.5 times more common in men than in women. Currently, drug medications, surgery, and lifestyle changes are common approaches to PD, while all of them focused on reducing the symptoms. Therefore, regenerative medicine based on stem cell (SC) therapies has raised a promising hope. Various types of SCs have been used in basic and experimental studies relevant to PD, including embryonic pluripotential stem cells, mesenchymal (MSCs) and induced pluripotent SCs (iPSCs). MSCs have several advantages over other counterparts. They are easily accessible which can be obtained from various tissues such as bone marrow, adipose tissue, peripheral blood, etc. with avoiding ethical problems. Therefore, MSCs is attractive clinically because there are no related ethical and immunological concerns . Further studies are needed to answer some crucial questions about the different issues in SC therapy. Accordingly, SC-based therapy for PD also needed more complementary evaluation in both basic and clinical study areas.
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