Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Covid-19 Vaccines’ Protectionover Time and Theneed for Booster Doses; a Systematic Review Publisher



Dadras O1, 2 ; Alinaghi SAS1 ; Karimi A3 ; Shojaei A1 ; Amiri A1 ; Mahdiabadi S3 ; Fakhfouri A4 ; Razi A3 ; Mojdeganlou H5 ; Mojdeganlou P6 ; Barzegary A4 ; Pashaei Z1 ; Afsahi A7 ; Shobeiri P3 Show All Authors
Authors
  1. Dadras O1, 2
  2. Alinaghi SAS1
  3. Karimi A3
  4. Shojaei A1
  5. Amiri A1
  6. Mahdiabadi S3
  7. Fakhfouri A4
  8. Razi A3
  9. Mojdeganlou H5
  10. Mojdeganlou P6
  11. Barzegary A4
  12. Pashaei Z1
  13. Afsahi A7
  14. Shobeiri P3
  15. Mehraeen E8
Show Affiliations
Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University ofMedical Sciences, Tehran, Iran
  2. 2. School of Public Health, Walailak University, Nakhon Si Thammarat, Thailand
  3. 3. School ofMedicine, Tehran University ofMedical Sciences, Tehran, Iran
  4. 4. School ofMedicine, Islamic Azad University, Tehran, Iran
  5. 5. Department of Pathology, Urmia University ofMedical Sciences, Urmia, Iran
  6. 6. School ofMedicine, Shahid Beheshti University ofMedical Sciences, Tehran, Iran
  7. 7. Department of Radiology, School ofMedicine, University of California, San Diego (UCSD), CA, United States
  8. 8. Department of Health Information Technology, Khalkhal University ofMedical Sciences, Khalkhal, Iran

Source: Archives of Academic Emergency Medicine Published:2022


Abstract

Introduction: Controversies existed regarding the duration of COVID-19 vaccines’ protection and whether receiving the usual vaccine doses would be sufficient for long-term immunity. Therefore, we aimed to systematically review the studies regarding the COVID-19 vaccines’ protection threemonths after getting fully vaccinated and assess the need for vaccine booster doses. Methods: The relevant literature was searched using a combination of keywords on the online databases of PubMed, Scopus, Web of Science, and Cochrane on September 17th, 2021. The records were downloaded and the duplicates were removed. Then, the records were evaluated in a two-step process, consisting of title/abstract and full-text screening processes, and the eligible records were selected for the qualitative synthesis. We only included original studies that evaluated the efficacy and immunity of COVID-19 vaccines three months after full vaccination.This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement to ensure the reliability of results. Results: Out of the 797 retrieved records, 12 studies were included, 10 on mRNA-based vaccines and two on inactivated vaccines. The majority of included studies observed acceptable antibody titers in most of the participants even after 6 months; however,it appeared that the titers could also decrease in a considerable portion of people. Due to the reduction in antibody titers and vaccine protection, several studies suggested administering the booster dose, especially for older patients and those with underlying conditions, such as patients with immunodeficiencies. Conclusion: Studies indicated that vaccine immunity decreases over time, making people more susceptible to contracting the disease. Besides, new variants are emerging, and the omicron variant is continuing to spread and escape fromthe immune system, indicating the importance of a booster dose. © 2022. Archives of Academic Emergency Medicine. All Rights Reserved.
Related Docs
1. Safety and Efficacy of Imatinib, Nilotinib, and Artesunate in Covid-19 Patients: A Systematic Review of Current Evidence, Anti-Infective Agents (2024)
2. Seroconversion Following the First, Second, and Third Dose of Sars-Cov-2 Vaccines in Immunocompromised Population: A Systematic Review and Meta-Analysis, Virology Journal (2022)
3. Covid-19 Vaccinations: The Unknowns, Challenges, and Hopes, Journal of Medical Virology (2022)
4. Public Acceptability of Covid-19 Vaccines and Its Predictors in Middle ‎Eastern/North African (Mena) Countries: A Systematic Review‎, Human Vaccines and Immunotherapeutics (2022)
Experts (# of related papers)
Nima Rezaei (2)
Seyed Ahmad Seyed Alinaghi (2)