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Fabrication and Characterization of Dextran/Nanocrystalline Β-Tricalcium Phosphate Nanocomposite Hydrogel Scaffolds Publisher Pubmed



Ghaffari R1 ; Salimikenari H1, 2 ; Fahimipour F3, 5 ; Rabiee SM4 ; Adeli H1 ; Dashtimoghadam E5
Authors
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Authors Affiliations
  1. 1. Faculty of Engineering & Technology, University of Mazandaran, P.O. Box 416, Babolsar, Iran
  2. 2. Department of Chemical and Materials Engineering, New Mexico State University, Las Cruces, 88003, NM, United States
  3. 3. Dental Biomaterials Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Mechanical Engineering, Babol Noshirvani University of Technology, P.O. Box 484, Babol, Iran
  5. 5. Department of Chemistry, University of North Carolina, Chapel Hill, 27599, NC, United States

Source: International Journal of Biological Macromolecules Published:2020


Abstract

Design of bioactive three-dimensional scaffolds to support bone tissue repair and regeneration become a key area of research in tissue engineering. Herein, porous hybrid hydrogels composed of dextran incorporated with nanocrystalline β-tricalcium phosphate (β-TCP) particles were tailor made as scaffolds for bone tissue engineering. β-TCP was successfully introduced within the dextran networks crosslinked through intermolecular ionic interactions and hydrogen bonding confirmed by FTIR spectroscopy. The effect of β-TCP content on equilibrium water uptake and swelling kinetics of composite hydrogels was investigated. It was found that the homogeneous distribution of β-TCP nanoparticles through the hydrogel matrix contributes to higher porosity and swelling capacity. In depth swelling measurements revealed that while in the early stage of swelling, water diffusion follows the Fick's law, for longer time swelling behavior of hydrogels undergo the second order kinetics. XRD measurements represented the formation of apatite layer on the surface of nanocomposite hydrogels after immersion in the SBF solution, which implies their bioactivity. Cell culture assays confirmed biocompatibility of the developed hybrid hydrogels in vitro. The obtained results converge to offer dextran/β-TCP nanocomposite hydrogels as promising scaffolds for bone regeneration applications. © 2020
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