Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering

Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering Publisher Pubmed

Khojasteh A^{1, 2} ; Fahimipour F^{3, 4} ; Eslaminejad MB⁵ ; Jafarian M¹ ; Jahangir S⁵ ; Bastami F⁶ ; Tahriri M^{3, 4, 7} ; Karkhaneh A⁷ ; Tayebi L^{3, 7, 8}

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1. Department of Oral and Maxillofacial Surgery, Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Craniomaxillofacial Surgery, School of Medicine, University of Antwerp, Antwerp, Belgium
3. Marquette University School of Dentistry, Milwaukee, 53233, WI, United States
4. Dental Biomaterials Department, School of Dentistry, Tehran University of Medical Scienï»¿ces, Tehran, Iran
5. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biologyand Technology, Tehran, Iran
6. Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
8. Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom

Source: Materials Science and Engineering C Published:2016

Abstract

Bone tissue engineering is sought to apply strategies for bone defects healing without limitations and short-comings of using either bone autografts or allografts and xenografts. The aim of this study was to fabricate a thin layer poly(lactic-co-glycolic) acid (PLGA) coated beta-tricalcium phosphate (β-TCP) scaffold with sustained release of vascular endothelial growth factor (VEGF). PLGA coating increased compressive strength of the β-TCP scaffolds significantly. For in vitro evaluations, canine mesenchymal stem cells (cMSCs) and canine endothelial progenitor cells (cEPCs) were isolated and characterized. Cell proliferation and attachment were demonstrated and the rate of cells proliferation on the VEGF released scaffold was significantly more than compared to the scaffolds with no VEGF loading. A significant increase in expression of COL1 and RUNX2 was indicated in the scaffolds loaded with VEGF and MSCs compared to the other groups. Consequently, PLGA coated β-TCP scaffold with sustained and localized release of VEGF showed favourable results for bone regeneration in vitro, and this scaffold has the potential to use as a drug delivery device in the future. © 2016

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Style	Citing Format
MLA	Khojasteh A, et al.. "Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering." Materials Science and Engineering C, vol. 69, no. , 2016, pp. 780-788.
APA	Khojasteh A, Fahimipour F, Eslaminejad MB, Jafarian M, Jahangir S, Bastami F, Tahriri M, Karkhaneh A, Tayebi L (2016). Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering. Materials Science and Engineering C, 69(), 780-788.
Chicago	Khojasteh A, Fahimipour F, Eslaminejad MB, Jafarian M, Jahangir S, Bastami F, Tahriri M, Karkhaneh A, Tayebi L. "Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering." Materials Science and Engineering C 69, no. (2016): 780-788.
Harvard	Khojasteh A et al. (2016) 'Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering', Materials Science and Engineering C, 69(), pp. 780-788.
Vancouver	Khojasteh A, Fahimipour F, Eslaminejad MB, Jafarian M, Jahangir S, Bastami F, et al.. Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering. Materials Science and Engineering C. 2016;69():780-788.
BibTex	@article{ author = {Khojasteh A and Fahimipour F and Eslaminejad MB and Jafarian M and Jahangir S and Bastami F and Tahriri M and Karkhaneh A and Tayebi L}, title = {Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering}, journal = {Materials Science and Engineering C}, volume = {69}, number = {}, pages = {780-788}, year = {2016} }
RIS	TY - JOUR AU - Khojasteh A AU - Fahimipour F AU - Eslaminejad MB AU - Jafarian M AU - Jahangir S AU - Bastami F AU - Tahriri M AU - Karkhaneh A AU - Tayebi L TI - Development of Plga-Coated Β-Tcp Scaffolds Containing Vegf for Bone Tissue Engineering JO - Materials Science and Engineering C VL - 69 IS - SP - 780 EP - 788 PY - 2016 ER -

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