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The Application of Direct Viral Cytopathic Hypothesis to Design Drug Trials in the Battle Against Covid-19 Publisher Pubmed



Ashraf MA1 ; Sherafat A2 ; Pourdast A3, 4 ; Nazemi P4 ; Mohraz M3
Authors
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Authors Affiliations
  1. 1. Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. School of Medicine, University of Central Lancashire, Preston, United Kingdom
  3. 3. Iranian Research Center for HIV/AIDS (IRCHA), District 6, Imam Khomeini Hospital, Keshavarz Blvd, Nosrat St, Tehran, Tehran Province, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran

Source: DARU# Journal of Pharmaceutical Sciences Published:2020


Abstract

COVID-19 has caused many deaths worldwide. Systemic complications alongside coagulopathy, and ARDS account for the majority of COVID-19 mortalities. The pathogenesis of the disease can be explained by two theories of direct viral cytopathy and systemic inflammatory cascade of events. ACE-2 is shown to be the cellular host receptor for SARS-CoV-2. It might be the key to explain the pathogenesis of systemic complications with a focus on the direct viral cytopathic hypothesis. Different medications tend to show up in many in vitro drug screens. However, more trials are needed to translate their application into in vivo efficacy. © 2020, Springer Nature Switzerland AG.
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