Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale? Publisher Pubmed



Mirzaei H1 ; Sahebkar A2 ; Jaafari MR3 ; Goodarzi M4 ; Mirzaei HR5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Faculty of Bioscience Engineering, Department of Biosystems, Katholieke Universiteit Leuven—KU Leuven, Heverlee, Belgium
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Physiology Published:2017


Abstract

Exosomes have emerged as one of the main players in intercellular communication. These small nano-sized particles have many roles in various physiological pathways in normal and abnormal cells. Exosomes can carry various cargos such as proteins, mRNAs, and miRNAs to recipient cells. Uptake of exosomes and their cargo can induce and/or inhibit different cellular and molecular pathways that lead to the alteration of cell behavior. Multiple lines of evidence have indicated that exosomes released from cancer cells can effect development of cancer in different stages. These particles and their cargo could regulate different processes such as tumor growth, metastasis, drug resistance, angiogenesis, and immune system functioning. It has been observed that exosomes can be used as potential diagnostic biomarkers in various cancer types. Moreover, some studies have used these particles as biological vehicles for delivery of various drugs such as doxorubicin, siRNAs, and miRNAs. Here, we summarized the findings on the role of exosomes in different pathological processes involved in cancer. Moreover, application of these particles as diagnostic and therapeutic biomarkers in different types of cancers is discussed. J. Cell. Physiol. 232: 3251–3260, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications, Current Medicinal Chemistry (2021)
2. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
3. The Extracellular Vesicles-Derived From Mesenchymal Stromal Cells: A New Therapeutic Option in Regenerative Medicine, Journal of Cellular Biochemistry (2018)
4. Texosome-Based Drug Delivery System for Cancer Therapy: From Past to Present, Cancer Biology and Medicine (2015)
5. Paper-Based Biosensors As Point-Of-Care Diagnostic Devices for the Detection of Cancers: A Review of Innovative Techniques and Clinical Applications, Frontiers in Oncology (2023)
6. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
7. The Role of Exosomes Contents on Genetic and Epigenetic Alterations of Recipient Cancer Cells, Iranian Journal of Basic Medical Sciences (2016)
8. Tumor-Derived Exosomes: The Next Generation of Promising Cell-Free Vaccines in Cancer Immunotherapy, OncoImmunology (2020)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (20)
Somayeh Ebrahimi Barough (5)
Other Related Docs
9. Microrna: A Novel Target of Curcumin in Cancer Therapy, Journal of Cellular Physiology (2018)
10. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)
11. Communication Between Stromal and Hematopoietic Stem Cell by Exosomes in Normal and Malignant Bone Marrow Niche, Biomedicine and Pharmacotherapy (2020)
12. Mesenchymal Stem Cells: A New Platform for Targeting Suicide Genes in Cancer, Journal of Cellular Physiology (2018)
13. Harnessing the Power of Exosomes for Diagnosis, Prognosis, and Treatment of Hematological Malignancies, Stem Cell Research and Therapy (2025)
14. Glioma and Exosome, Letters in Applied NanoBioScience (2022)
15. Glioblastoma: Exosome and Microrna As Novel Diagnosis Biomarkers, Cancer Gene Therapy (2016)
16. Development and Clinical Application of Tumor-Derived Exosomes in Patients With Cancer, Current Stem Cell Research and Therapy (2022)
17. Exosomes and Micrornas: New Potential Therapeutic Candidates in Alzheimer Disease Therapy, Journal of Cellular Physiology (2019)
18. Microrna: Relevance to Stroke Diagnosis, Prognosis, and Therapy, Journal of Cellular Physiology (2018)
19. Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer, Molecular Therapy Nucleic Acids (2018)
20. Cancer Stem Cells and Oral Cancer: Insights Into Molecular Mechanisms and Therapeutic Approaches, Cancer Cell International (2020)
21. Exosomal Micrornas As Potential Circulating Biomarkers in Gastrointestinal Tract Cancers: A Systematic Review Protocol, Systematic Reviews (2017)
22. Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition in Cancer: Nanotechnology Comes Into View, Journal of Cellular Physiology (2018)
23. Influenza Vaccine: Where Are We and Where Do We Go?, Reviews in Medical Virology (2019)
24. Early Diagnosis of Breast and Ovarian Cancers by Body Fluids Circulating Tumor-Derived Exosomes, Cancer Cell International (2020)
25. State of the Art in Microrna As Diagnostic and Therapeutic Biomarkers in Chronic Lymphocytic Leukemia, Journal of Cellular Physiology (2018)
26. Teeth-Derived Stem Cells: A Source for Cell Therapy, Journal of Cellular Physiology (2019)
27. Micrornas-Based Imaging Techniques in Cancer Diagnosis and Therapy, Journal of Cellular Biochemistry (2017)
28. Micro-Rnas As Critical Regulators of Matrix Metalloproteinases in Cancer, Journal of Cellular Biochemistry (2018)
29. Extracellular Vesicles Biogenesis, Isolation, Manipulation and Genetic Engineering for Potential in Vitro and in Vivo Therapeutics: An Overview, Frontiers in Bioengineering and Biotechnology (2022)
30. Emerging Roles of Exosomal Mirnas in Breast Cancer Drug Resistance, IUBMB Life (2019)
31. Micrornas and Exosomes in Depression: Potential Diagnostic Biomarkers, Journal of Cellular Biochemistry (2018)
32. Mirna-Based Strategy for Modulation of Influenza a Virus Infection, Epigenomics (2018)
33. Predictive and Therapeutic Biomarkers in Chimeric Antigen Receptor T-Cell Therapy: A Clinical Perspective, Journal of Cellular Physiology (2019)
34. Imaging Techniques: New Avenues in Cancer Gene and Cell Therapy, Cancer Gene Therapy (2017)
35. Liquid Biopsy in Thyroid Cancer: New Insight, International Journal of Hematology-Oncology and Stem Cell Research (2018)
36. Microrna in Leukemia: Tumor Suppressors and Oncogenes With Prognostic Potential, Journal of Cellular Physiology (2019)
37. Micrornas and Exosomes: Cardiac Stem Cells in Heart Diseases, Pathology Research and Practice (2022)
38. Nanoparticles As New Tools for Inhibition of Cancer Angiogenesis, Journal of Cellular Physiology (2018)
39. Therapeutic Application of Multipotent Stem Cells, Journal of Cellular Physiology (2018)
40. Recent Advances in the Roles of Exosomal Micrornas (Exomirs) In Hematologic Neoplasms: Pathogenesis, Diagnosis, and Treatment, Cell Communication and Signaling (2023)
41. Tumor-Derived Exosomal Micrornas and Proteins As Modulators of Macrophage Function, Journal of Cellular Physiology (2019)
42. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis, Journal of Neuroimmune Pharmacology (2025)
43. Increasing the Sensitivity and Accuracy of Detecting Exosomes As Biomarkers for Cancer Monitoring Using Optical Nanobiosensors, Cancer Cell International (2024)
44. The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases, Molecular Neurobiology (2019)
45. Role of Non-Coding Rnas in Neuroblastoma, Cancer Gene Therapy (2023)
46. Exosome Application in Treatment and Diagnosis of B-Cell Disorders: Leukemias, Multiple Sclerosis, and Arthritis Rheumatoid, Cellular and Molecular Biology Letters (2022)
47. Exosomal Micrornas Derived From Mesenchymal Stem Cells: Cell-To-Cell Messages, Cell Communication and Signaling (2020)
48. Circulating Micrornas As Diagnostic and Therapeutic Biomarkers in Gastric and Esophageal Cancers, Journal of Cellular Physiology (2018)
49. Designer Exosomes: A New Platform for Biotechnology Therapeutics, BioDrugs (2020)
50. The Emerging Role of Exosomal Mirnas As a Diagnostic and Therapeutic Biomarker in Mycobacterium Tuberculosis Infection, Molecular Medicine (2021)