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On the Benefit of Nanocurcumin on Aluminium Phosphide-Induced Cardiotoxicity in a Rat Model Publisher



Fakhraei N1 ; Hashemibakhsh R2 ; Rezayat SM2, 3, 4 ; Abdolghafari AH2, 5 ; Jaafari MR6, 7 ; Mumtaz F8 ; Mousavi SE3
Authors
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Authors Affiliations
  1. 1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran
  6. 6. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Pharmacology, School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Research Journal Published:2019


Abstract

Objective(s): Cardiotoxicity is considered the main cause of death in aluminum phosphide (ALP)-poisoned cases. Curcumin, an active ingredient of turmeric, is a potent protective polyphenol compound against cardiac diseases including cardiotoxicity. This study aimed to examine the probable cardioprotection potential of nanomicelle curcumin in a rat model of ALP-induced cardiotoxicity. Methods: The rats were orally intoxicated with ALP (12 mg/kg, p.o.; 1/4 LD50). In treatment groups, curcumin (50 mg/kg, i.p.) and nanocurcumin (10, 20 and 50 mg/ kg, i.p.) were administered intraperitoneally 30 min following ALP administration. Twenty four hrs subsequent to ALP intoxication, the hearts were dissected out for evaluation of oxidative stress and lipid peroxidation (LPO) markers such as thiol, reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH) levels, malondialdehyde (MDA) and the ferric reducing ability of plasma (FRAP). Results: In fact, ALP increased MDA as well as ROS and SOD levels. On the other hand, ALP significantly lowered thiol, GHS and FRAP markers. In contrast, nanocurcumin successfully could reverse the increases in MDA as well as SOD, ROS and GSH. Simultaneously, it significantly enhanced thiol, GHS and FRAP markers. Moreover, curcumin markedly lowered MDA, ROS and SOD levels while increased thiol and GSH contents. Conclusions: Overall, the present data demonstrated the cardio-protective effects of nanocurcumin in this model of cardiotixicity. Further, it suggested that this cardioprotecton is possibly mediated by the ability of nanocurcumin to confront the oxidative stress and LPO resulting from ALP intoxication of the heart tissue. © 2019 Tehran University of Medical Sciences. All rights reserved.
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