Prevalence of Methicillin-Resistant Staphylococcus Aureus Isolated From Burn Patients in Iran: A Systematic Review and Meta-Analysis Publisher Pubmed



Emaneini M¹ ; Beigverdi R¹ ; Van Leeuwen WB² ; Rahdar H¹ ; Karamizarandi M¹ ; Hosseinkhani F² ; Jabalameli F¹ Show Affiliations
Source: Journal of Global Antimicrobial Resistance Published:2018

Abstract

Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is considered a major cause of infection and mortality in burn patients, especially when nosocomially acquired. However, limited information is available on the prevalence of MRSA among burn patients in Iran. Methods: A systematic search was performed using different electronic databases including Medline (via PubMed), Embase, Web of Science and Iranian Database. A meta-analysis was performed using Comprehensive Meta-Analysis Software (BioStat v.2.2). Use of a fixed- or random-effects model was used based on a heterogeneity test, and publication bias was assessed using Begg rank correlation and Egger weighted regression methods. Results: Of 555 articles published from January 2000 to January 2016, 13 studies were included in this review. The meta-analyses showed that the prevalence of MRSA infection in burn patients was 77.9% (95% confidence interval 70.2–84.0%) among culture-positive cases. Conclusions: The results of this study indicate that the prevalence of MRSA among burn patients is very high in Iran. Thus, a comprehensive infection control strategy based on hand hygiene, education and training in antibiotic prescribing, environmental cleaning, contact precautions, good antibiotic stewardship and an active surveillance system on the basis of international criteria is urgently needed. © 2018 International Society for Chemotherapy of Infection and Cancer