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Micrornas and Exosomes in Depression: Potential Diagnostic Biomarkers Publisher Pubmed



Tavakolizadeh J1 ; Roshanaei K2 ; Salmaninejad A3 ; Yari R4 ; Nahand JS5 ; Sarkarizi HK6 ; Mousavi SM7 ; Salarinia R8 ; Rahmati M9 ; Mousavi SF10 ; Mokhtari R11 ; Mirzaei H12
Authors
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Authors Affiliations
  1. 1. Department of Psychology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  2. 2. Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
  3. 3. Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran
  4. 4. Department of Biology, Faculty of Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran
  5. 5. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Medicine, Department of Anatomical Sciences and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  9. 9. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  10. 10. Department of Genetics, Faculty of Basic Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  11. 11. Department of Neuroscience and Physiology, State University of New York − Upstate Medical University, Syracuse, NY, United States
  12. 12. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Cellular Biochemistry Published:2018


Abstract

Depression is known as one of important psychiatric disorders which could be associated with disability among various populations. Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV) and international statistical classification of diseases and related health problems (ICD-10) could be used as subjective diagnostic schemes for identification of mental disorders such as depression. Utilization of subjective diagnostic schemes are associated with limitations. Hence, it seems that employing of new diagnosis platforms is required. Multiple lines of evidence indicated that measurement of several biomarkers could be useful for detection patients with depression. Among of various types of biomarkers, microRNAs (miRNAs) have been emerged as powerful tools for diagnosis patients with depression. MiRNAs are small non-coding RNAs which act as epigenetic regulators. It has been showed that these molecules have critical roles in pathogenesis of many diseases such as depression. These molecules exert their effects via targeting a variety of cellular and molecular pathways involved in initiation and progression of depression. Hence, miRNAs could be used as diagnostic and therapeutic biomarkers in patients with depression. Besides miRNAs, exosomes as nano- carriers could have been emerged as diagnostic biomarkers in several diseases such as depression. These vesicles are able to carry several cargos such as DNAs, proteins, mRNAs, and miRNAs to recipient cells. Here, we summarized several miRNAs involved in pathogenesis and response to treatment of depression which could be used as diagnostic biomarkers. Moreover, we highlighted exosomes as new diagnostic biomarkers for patients with depression. © 2017 Wiley Periodicals, Inc.
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